Aging Clinical and Experimental Research

, Volume 25, Issue 6, pp 711–714

Plasma kinetic of ingested essential amino acids in healthy elderly people

  • Anna Maria Condino
  • Roberto Aquilani
  • Evasio Pasini
  • Paolo Iadarola
  • Simona Viglio
  • Manuela Verri
  • Luca D’Agostino
  • Federica Boschi
Short Communication

DOI: 10.1007/s40520-013-0099-5

Cite this article as:
Condino, A.M., Aquilani, R., Pasini, E. et al. Aging Clin Exp Res (2013) 25: 711. doi:10.1007/s40520-013-0099-5

Abstract

The purpose of this study was to investigate whether the documented difficulties of physiological amounts of essential amino acids (EAAs) (7 g) to induce protein synthesis could be reflected in a simple method adaptable to a clinical setting. Sixteen healthy individuals, nine elderly (75.3 ± 3.5 years), and seven young (28 ± 2.5 years) were enrolled in the study. Five minutes before EAA ingestion (baseline) and 20, 40, 60, 90, 120, 180 min after EAA ingestion, venous blood samples were taken from the ante-cubital vein to determine the concentrations of EAAs (μmol/L). The results show that plasma EAA increases were significantly higher in old than in young persons at the considered time points (from p < 0.004 to p < 0.001) (unpaired Student t test). However, the velocity rate of the increasing was slower in old subjects than in young group. The study shows that EAAs ingestion by old subject is associated with reduced muscle EAA uptake.

Keywords

Essential amino acids (EAAs)Skeletal muscleElderlyEAAs plasma profile

Copyright information

© Springer International Publishing Switzerland 2013

Authors and Affiliations

  • Anna Maria Condino
    • 1
  • Roberto Aquilani
    • 2
  • Evasio Pasini
    • 3
  • Paolo Iadarola
    • 4
  • Simona Viglio
    • 5
  • Manuela Verri
    • 6
  • Luca D’Agostino
    • 7
  • Federica Boschi
    • 1
  1. 1.Dipartimento di Scienze del FarmacoUniversità degli Studi di PaviaPaviaItaly
  2. 2.Servizio di Fisiopatologia Metabolico-Nutrizionale e Nutrizione Clinica, Fondazione S. Maugeri, IRCCSIstituto Scientifico di MontescanoMontescanoItaly
  3. 3.Fondazione S. Maugeri, IRCCSIstituto Scientifico di LumezzaneLumezzaneItaly
  4. 4.Dipartimento di Biologia e BiotecnologieUniversità degli Studi di PaviaPaviaItaly
  5. 5.Dipartimento di Medicina MolecolareUniversità degli Studi di PaviaPaviaItaly
  6. 6.Dipartimento di Medicina Legale, Scienze Forensi e Farmaco-Tossicologiche “A. Fornari”, Sezione di Scienze Farmacologiche e TossicologicheUniversità degli Studi di PaviaPaviaItaly
  7. 7.Dipartimento di Scienze Chirurgiche, Rianimatorie-Riabilitative e dei Trapianti d’OrganoUniversità degli Studi di PaviaPaviaItaly