Original Article

Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity

, Volume 18, Issue 3, pp 305-310

First online:

Two-year changes in generic and obesity-specific quality of life after gastric bypass

  • Javier MarAffiliated withClinical Management Service, Alto Deba HospitalHealth Research Unit (West Gipuzkoa), Alto Deba Hospital Email author 
  • , Jan KarlssonAffiliated withCentre for Health Care Sciences, Department of Medicine, School of Health and Medical Sciences, Örebro University Hospital
  • , Arantzazu ArrospideAffiliated withHealth Research Unit (AP-OSIs Gipuzkoa), Alto Deba Hospital
  • , Blanca MarAffiliated withSurgery Department, Donostia Hospital
  • , Gabriel Martínez de AragónAffiliated withSurgery Department, Txagorritxu Hospital
  • , Cándido Martinez-BlazquezAffiliated withSurgery Department, Txagorritxu Hospital

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The study objectives were to assess 2-year changes in health-related quality of life (HRQL) after gastric bypass in patients with severe obesity and to analyze HRQL improvements in relation to weight loss after bariatric surgery. This was a prospective intervention study with consecutive patients referred to two bariatric surgical units in the Basque Country. We used both generic (Short Form Health Survey, SF-36 and EuroQol, EQ-5D), and specific questionnaires (Moorehead-Ardelt, MA II and Obesity-related Problems Scale, OP). Effect sizes and receiver operating characteristic (ROC) curves were calculated to assess the change in quality of life. Spearman’s correlation coefficient was calculated to assess whether there was an association between changes in body mass index (BMI) and HRQL. Of 82 patients who underwent surgery, 79 were followed-up for 2 years. Mean weight loss was 37 % of body weight (49 kg) and BMI fell from 50.6 to 31.8. The initial problems and final improvements were greater in the physical dimensions. Considerable benefits were observed in assessments with all the instruments used. However, the changes in weight/BMI and HRQL were not linear. The comparison with general population showed a similar profile in SF-36 dimensions after surgery. Severely obese patients have lower perceived health across all dimensions of quality of life. Moreover, the impact on functioning is so important that severe obesity can be described as a cause of disability that disappears 2 years after surgical treatment. ROC curves indicate that most of the HRQL measures are poor predictors of change in terms of reduction in body weight or BMI.


Morbid obesity Gastric bypass Quality of life Disability ROC curves