Review Article

High Blood Pressure & Cardiovascular Prevention

, Volume 21, Issue 2, pp 81-87

First online:

Hypertensive Heart Disease and Obesity: A Complex Interaction Between Hemodynamic and Not Hemodynamic Factors

  • Riccardo SarzaniAffiliated withInternal Medicine and Geriatrics, “Hypertension Excellence Centre” of the European Society of Hypertension, Department of Clinical and Molecular Sciences, University “Politecnica delle Marche”, Italian National Research Centre on Aging “U. Sestilli”, IRCCS-INRCA Email author 
  • , Marica BordicchiaAffiliated withInternal Medicine and Geriatrics, “Hypertension Excellence Centre” of the European Society of Hypertension, Department of Clinical and Molecular Sciences, University “Politecnica delle Marche”, Italian National Research Centre on Aging “U. Sestilli”, IRCCS-INRCA
  • , Francesco SpannellaAffiliated withInternal Medicine and Geriatrics, “Hypertension Excellence Centre” of the European Society of Hypertension, Department of Clinical and Molecular Sciences, University “Politecnica delle Marche”, Italian National Research Centre on Aging “U. Sestilli”, IRCCS-INRCA
  • , Paolo Dessì-FulgheriAffiliated withInternal Medicine and Geriatrics, “Hypertension Excellence Centre” of the European Society of Hypertension, Department of Clinical and Molecular Sciences, University “Politecnica delle Marche”, Italian National Research Centre on Aging “U. Sestilli”, IRCCS-INRCA
  • , Massimiliano FedecostanteAffiliated withInternal Medicine and Geriatrics, “Hypertension Excellence Centre” of the European Society of Hypertension, Department of Clinical and Molecular Sciences, University “Politecnica delle Marche”, Italian National Research Centre on Aging “U. Sestilli”, IRCCS-INRCA

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Abstract

The worldwide prevalence of obesity has nearly doubled, with an increase in obesity-related cardiovascular disease and mortality. Several factors are involved in the genesis of hypertension and hypertensive heart disease (HHD) in overweight/obesity. This review is focused on bridging factors between excessive adiposity and HHD, presenting a unifying hypothesis of vascular–metabolic syndrome, where an “handicap” of the natriuretic peptide system has a central role both in adipocyte dysmetabolism as well as in increased blood pressure and HHD.

Keywords

Obesity Adipocyte Hypertensive heart disease Cardiovascular risk Natriuretic peptides