Molecular Diagnosis & Therapy

, Volume 18, Issue 1, pp 93–95

Genetic Markers for Cardiovascular Disease in Psoriasis: The Missing Piece

  • Tiago Torres
  • Andrea Chiricozzi
  • Sergio Chimenti
  • Rosita Saraceno
Short Communication

DOI: 10.1007/s40291-013-0056-1

Cite this article as:
Torres, T., Chiricozzi, A., Chimenti, S. et al. Mol Diagn Ther (2014) 18: 93. doi:10.1007/s40291-013-0056-1

Abstract

Psoriasis is a common, chronic inflammatory disease associated with serious comorbidities. Severe psoriasis has been associated with increase cardiovascular mortality, due to a higher prevalence of traditional cardiovascular risk factors such as diabetes, hypertension, dyslipidemia and obesity, and premature atherosclerosis, as a consequence of its systemic inflammation. It is likely that there are genetic links between psoriasis, its comorbidities and cardiovascular disease. Although there are some studies performed in rheumatoid arthritis reporting some gene polymorphisms that may be associated with cardiovascular diseases and comorbidities these studies are lacking in psoriasis. Recognizing genetic markers that could predict which patients are at risk of developing psoriasis-linked cardiovascular comorbidities would facilitate screening strategies and permit an earlier management of cardiovascular risk factors, with important clinical implications.

Copyright information

© Springer International Publishing Switzerland 2013

Authors and Affiliations

  • Tiago Torres
    • 1
    • 2
  • Andrea Chiricozzi
    • 3
  • Sergio Chimenti
    • 3
  • Rosita Saraceno
    • 3
  1. 1.Serviço de DermatologiaCentro Hospitalar do PortoPortoPortugal
  2. 2.Instituto Ciências Abel SalazarUniversity of PortoPortoPortugal
  3. 3.Department of DermatologyUniversity of Rome Tor VergataRomeItaly

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