, Volume 17, Issue 1, pp 57-62
Date: 19 Jan 2013


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In the EU, the approved use of erlotinib (Tarceva®), an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, has recently been expanded to include first-line treatment of locally advanced or metastatic non-small-cell lung cancer (NSCLC) in patients with EGFR-activating mutations. In randomized, open-label, phase III clinical trials, oral erlotinib reduced the risk of progression, improved response rates, and was well tolerated relative to standard platinum-based doublet chemotherapy in Caucasian and Asian populations with advanced NSCLC with EGFR-activating mutations.

The manuscript was reviewed by A. Bearz, Department of Medical Oncology, National Cancer Institute, Aviano, Italy; E. Cortesi, Medical Oncology B, La Sapienza University, Rome, Italy.