, Volume 1433, Issue 1, p 12

Bicalutamide

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A 60-year-old man developed gynaecomastia during treatment with bicalutamide for advanced prostate cancer. He was treated with bicalutamide 150mg daily for 2.5 years [route not stated]. Six months after starting treatment, he developed progressive enlargement of his breasts with bilateral pain. His bicalutamide was withdrawn and his pain resolved. However, the size of his breasts remained the same and caused social embarrassment. Surgical correction was carried out.

Author comment: "Gynecomastia occurs in up to 80% of patients who receive nonsteroidal antiandrogens (e.g., bicalutamide, flutamide, or nilutamide)".