, Volume 30, Issue 7, pp 503-512
Date: 20 Apr 2013

Therapeutic Management of Primary Immunodeficiency in Older Patients

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Abstract

Primary immunodeficiency disease (PID) has traditionally been viewed as a group of illnesses seen in the paediatric age group. New advances in diagnosis and treatment have led to an increase in the number of elderly PID patients. However, there is lack of research evidence on which to base clinical management in this group of patients. Management decisions often have to be based therefore on extrapolations from other patient cohorts or from younger patients. Data from the European Society for Immunodeficiencies demonstrates that the vast majority of elderly patients suffer from predominantly antibody deficiency syndromes. We review the management of PID disease in the elderly, with a focus on antibody deficiency disease.

The European Society for Immunodeficiencies (ESID) Registry is based on contributions from the following national registries: CEREDIH (France), REDIP (Spain), PID-NET (Germany), UKPIN (UK), IPINET (Italy), AGPI (Austria), the Netherlands, Czech Republic. Additional contributions were received from the following countries: Turkey, Poland, Ireland, Portugal, Belgium, Switzerland, Slovakia, Sweden, Slovenia, Croatia, Serbia, Greece, Belarus, Russia, Hungary, Romania, Ukraine, Estonia, Lithuania, Egypt.
N. Verma and A. Thaventhiran contributed equally to this work.