CNS Drugs

, Volume 27, Issue 10, pp 799–815

Neuroprotection in Multiple Sclerosis: A Therapeutic Approach

  • Amir-Hadi Maghzi
  • Alireza Minagar
  • Emmanuelle Waubant
Review Article

DOI: 10.1007/s40263-013-0093-7

Cite this article as:
Maghzi, AH., Minagar, A. & Waubant, E. CNS Drugs (2013) 27: 799. doi:10.1007/s40263-013-0093-7

Abstract

Multiple sclerosis (MS) is a demyelinating disease of the central nervous system that is pathologically characterized by inflammatory demyelination and neurodegeneration. Axonal damage, along with neuronal loss, occurs from disease onset and may lead to progressive and permanent disability. In contrast with the inflammatory pathways, the molecular mechanisms leading to MS neurodegeneration remain largely elusive. With improved understanding of these mechanisms, new potential therapeutic targets for neuroprotection have emerged. We review the current understanding of neurodegenerative processes at play in MS and discuss potential outcome measures and targets for neuroprotection trials.

Copyright information

© Springer International Publishing Switzerland 2013

Authors and Affiliations

  • Amir-Hadi Maghzi
    • 1
  • Alireza Minagar
    • 2
  • Emmanuelle Waubant
    • 1
  1. 1.Multiple Sclerosis Center, Department of NeurologyUniversity of California San Francisco (UCSF)San FranciscoUSA
  2. 2.Department of NeurologyLouisiana State University Health Sciences CenterShreveportUSA

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