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Recent Progress in Understanding the Pathophysiology of Post-Traumatic Stress Disorder

Implications for Targeted Pharmacological Treatment

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Abstract

Post-traumatic stress disorder (PTSD) is a common and chronic anxiety disorder that can result after exposure to a traumatic event. Though our understanding of the aetiology of PTSD is incomplete, several neurobiological systems have been implicated in the pathophysiology and vulnerability towards developing PTSD after trauma exposure. We aimed to provide a concise review of benchmark findings in important neurobiological systems related to the aetiology and maintenance of PTSD symptomology. Specifically, we discuss functional aetiologies in the noradrenergic, serotonergic, endogenous cannabinoid and opioid systems as well as the hypothalamic-pituitary adrenal (HPA) axis. This article provides a succinct framework to appreciate the current understanding of neurobiological mechanisms related to the pathophysiology of PTSD and how these findings may impact the development of future, targeted pharmacological treatments for this debilitating disorder.

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Acknowledgements

This project was supported by the National Institutes of Health through the following awards: R21 MH081103 (ARRA), R21 MH096105-01A1, R21 MH085627 and R01 MH096876-01A1. The authors have no conflicts of interest that are directly relevant to the content of this article.

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  1. Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Christopher R. Bailey

  2. Department of Psychiatry and Radiology, NYU School of Medicine, Molecular Imaging Program for Mood and Anxiety Disorders, One Park Avenue, 8th Floor, Room 225, New York, NY, 10016, USA

    Elisabeth Cordell, Sean M. Sobin & Alexander Neumeister

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Correspondence to Alexander Neumeister.

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Bailey, C.R., Cordell, E., Sobin, S.M. et al. Recent Progress in Understanding the Pathophysiology of Post-Traumatic Stress Disorder. CNS Drugs 27, 221–232 (2013). https://doi.org/10.1007/s40263-013-0051-4

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