CNS Drugs

, Volume 26, Issue 11, pp 937–948

Management of Pain in Parkinson’s Disease


  • Munazza Sophie
    • Department of NeurologyColumbia University
    • Department of NeurologyColumbia University
    • The Neurological Institute of New York
Therapy in Practice

DOI: 10.1007/s40263-012-0005-2

Cite this article as:
Sophie, M. & Ford, B. CNS Drugs (2012) 26: 937. doi:10.1007/s40263-012-0005-2


Pain is a common symptom in Parkinson’s disease (PD) and accounts for substantial morbidity in up to 80 % of patients. Despite contributing to disease-related discomfort and disability, pain in PD frequently goes underacknowledged and undertreated in clinical practice. Although the exact underlying neurophysiology is unclear, there is increasing understanding of the role of the basal ganglia in somatosensory processing, as well as involvement of additional brainstem structures and non-dopaminergic pathways; appreciation of these mechanisms has implications for treatment strategies. Categorizing painful symptoms based on their clinical description into musculoskeletal, dystonic, radicular-peripheral neuropathic and central pain categories provides a useful framework for management. Importantly, these symptoms should be evaluated in relation to motor symptoms and dopaminergic therapy. A multi-disciplinary approach is recommended as follows: physical therapy, liaison with pain management and consultations to rheumatological, orthopaedic and neurosurgical services should be considered.

Copyright information

© Springer International Publishing Switzerland 2012