Original Research Article

Clinical Drug Investigation

, Volume 33, Issue 5, pp 343-349

First online:

Open Access This content is freely available online to anyone, anywhere at any time.

Economic Evaluation of 5-Grass Pollen Tablets Versus Placebo in the Treatment of Allergic Rhinitis in Adults

  • Matteo RuggeriAffiliated withFaculty of Economics, Università Cattolica del Sacro Cuore
  • , Marco OradeiAffiliated withTechnology Evaluation Unit, Policlinico Universitario A. Gemelli
  • , Franco FratiAffiliated withMedical and Scientific Department, Stallergenes Email author 
  • , Paola PuccinelliAffiliated withMedical and Scientific Department, Stallergenes
  • , Cristina RomaoAffiliated withMarket Access Department, Stallergenes SA
  • , Ilaria Dell’AlbaniAffiliated withMedical and Scientific Department, Stallergenes
  • , Cristoforo IncorvaiaAffiliated withAllergy/Pulmonary Rehabilitation, ICP Hospital
  • , Americo CicchettiAffiliated withFaculty of Economics, Università Cattolica del Sacro Cuore

Abstract

Background

Allergen immunotherapy (AIT) is aimed at modifying the immune response to a causative allergen, thereby reducing clinical symptoms and symptomatic medication intake and improving quality of life. Long-term AIT research has led to the development of 5-grass pollen tablets, currently indicated for the treatment of grass pollen-induced allergic rhinitis (AR).

Methods

A post-hoc analysis was conducted using the Average Adjusted Symptom Score (AAdSS) to compare the effect of treatment of AR with 5-grass pollen tablets versus placebo treatment. Using the results of the VO34.04 and VO53.06 trials and economic data, cost-effectiveness analysis of 5-grass pollen tablet treatment was performed from the Italian third-party payer perspective with cost data derived from a study of 2008 updated to 2011. Also a societal perspective was considered by using the costs related to the losses of productivity by following the human capital approach. Using the results of the analysis, the estimated receiver-operating characteristic curve was plotted to evaluate medication effectiveness in terms of quality-adjusted life years (QALYs) and a decision tree constructed to model the possible outcomes and costs for adults and paediatric patients with a low, medium, and high AAdSS. Finally, probabilistic sensitivity analysis was conducted to test the robustness of the results as well as their consistency at an assumed cost-effectiveness threshold of € 30,000/QALY.

Results

The results indicate that compared to the placebo, the 5-grass pollen tablet treatment provides a benefit of 0.127 QALYs in medium AAdSS patients and of 0.143 QALYs in high AAdSS patients. The 5-grass pollen tablet treatment was found to cost € 1,024/QALY for patients with a medium AAdSS and € 1,035/QALY for patients with a high AAdSS. Of all the simulations performed in the probabilistic sensitivity analysis, 99 % indicated that the incremental cost-effectiveness ratio of the 5-grass pollen tablet treatment was below the threshold of € 30,000/QALY in patients with medium and high AAdSS, whereas it was found to be dominated in 67 % of simulations related to patients with low AAdSS.

Conclusion

The 5-grass pollen tablet is a cost-effective treatment for adult AR patients with a medium or high AAdSS. This finding should be carefully considered when deciding the management strategy for these patients.