Transesophageal Monitoring in Anaesthesia: An Update
Transesophageal echocardiography (TEE) is increasingly used for diagnosis and monitoring in a number of clinical areas for assessment of cardiac structure and function. The use of TEE is well established in cardiac surgery but in non-cardiac surgery, TEE is recommended in preexistent cardiovascular disease causing hemodynamic compromise or in the presence of refractory hemodynamic instability or hypoxemia. Real-time 3-dimensional TEE provides exceptional images and unique views which have been pivotal in the success of minimally invasive surgery and transcatheter interventions. Although TEE is a relatively safe procedure, guidelines for standardized training, techniques and research protocols are recommended by most august bodies. The use of simulation-based learning has aided training by providing structured training opportunities and sufficient training time. TEE is a semi-invasive, portable, safe and readily available imaging modality that is likely to see an upsurge due to innovations in technology, miniaturization and an increase in minimally invasive procedures.
KeywordsTransesophageal Trends Cardiac surgery Thoracic surgery 3-dimensional TEE Interventional/methods Perioperative period
The therapeutic impact of TEE is difficult to assess but initiation of cardiac drugs, optimal fluid management, changes in the anaesthetic and surgical plan, and additional surgical procedures after a TEE examination have been shown to be beneficial especially in category I indications [3, 4].
Significant advances in technology have made TEE accessible and affordable to clinicians thereby enabling either a comprehensive study or even a limited, “goal-focused” examination aimed at addressing specific clinical concerns [5••]. This article aims to highlight recent trends and developments in TEE, and focuses on the ever-expanding list of indications for TEE in anaesthesia.
Appropriateness of TEE in Surgery
Guidelines have been formulated to ensure that both transthoracic and transesophageal echocardiography are used appropriately in clinical scenarios . 202 indications have been identified and scored for appropriateness with an aim to improving patient care and health outcomes in a cost-effective manner. Generally, the use of echocardiography is considered to be appropriate when it is used to make a diagnosis, assess a change in clinical status or is likely to influence patient management. This includes the use of TEE to assess valvular abnormalities and to confirm the presence or absence of aortic pathology, intra-cardiac shunts and embolic sources .
TEE in Cardiothoracic Surgery
TEE in Aortic Valve Surgery
Aortic valve repair is a challenging but viable alternative to prosthetic valve replacement in the younger patient with aortic regurgitation (AR). Intraoperative TEE is used to assess aortic valve morphology, severity of AR, mechanisms of AR based on leaflet mobility, as well as foster a systematic approach to surgery .
TEE in Thoracic Surgery
Patients with pre-existing respiratory disease and associated right ventricular (RV) impairment undergoing non-cardiac thoracic surgery may benefit from intraoperative TEE monitoring. RV dysfunction and left ventricular diastolic dysfunction (LVDD) have both been implicated as risk factors for atrial arrhythmias following thoracic surgery . TEE has recently been used to assess the effects of intraoperative one-lung ventilation strategies on the right ventricle. RV function appears to be less impaired by pressure-controlled ventilation when compared to volume-controlled mechanical ventilation .
TEE in Thoracic Transplantation Surgery
TEE in Extracorporeal Membrane Oxygenation
Extracorporeal membrane oxygenation (ECMO) provides hemodynamic and/or respiratory support to critically ill patients using a modified cardiopulmonary bypass circuit and large-bore cannulae placed in or near the heart. The two modes used are venovenous (VV) and venoarterial (VA) ECMO. TEE monitoring is used to diagnose anatomical abnormalities of the heart and exclude reversible causes of hemodynamic instability prior to cannulation. It is also used to assist the correct placement of cannulae, monitor the response to ECMO, identify any complications, consider the readiness to wean from ECMO and finally oversee the weaning process .
TEE in Pulmonary Hypertension
Pulmonary hypertension (PH) and RV failure are associated with significant mortality . The major risk factors are preoperative RV impairment, increased pulmonary vascular resistance and the type of surgical procedure . The risk is greatest in surgical procedures associated with marked systemic inflammatory response, rapid blood loss, venous embolism (air, carbon dioxide, fat or cement) and loss of pulmonary vasculature .
The 2-dimensional (2D) echocardiographic features and the Doppler indices required for the evaluation of PH have been extensively reviewed . Chronic RV pressure overload may be diagnosed by enlarged right heart, impaired RV systolic function and a flattened interventricular septum causing a small D-shaped left ventricle . Patients with PH will have significant pulmonary regurgitation with at least moderate tricuspid regurgitation (TR) secondary to tricuspid annular dilatation, altered RV geometry and apical displacement of the tricuspid leaflets . A pulsed-wave Doppler waveform analysis of the pulmonary artery flow velocity profile obtained from one of the upper oesophageal views can provide evidence of increased impedance and/or decreased compliance of the pulmonary vascular tree .
TEE in Diastolic Dysfunction
TEE in Non-cardiac Surgery
In the past, use of TEE in non-cardiac surgery has been limited by acquisition costs, lack of training, experience, familiarity and perhaps the lack of comprehension of its true potential . Intraoperative TEE is recommended in non-cardiac surgery when the patient has known or suspected cardiovascular disease that might result in severe hemodynamic, pulmonary or neurologic compromise or when unexplained and refractory intraoperative hemodynamic instability or hypoxemia occurs. The goal is to determine the cause of hemodynamic instability and to guide therapeutic interventions required to treat the cause . However, there are no outcome studies in which TEE has been randomized as an intervention to assess patient outcome [5••]. Misdiagnosis is also a likely risk and the importance of knowledge, training and experience must be stressed.
TEE in Emergency Surgery
Rescue echocardiography has been used successfully in patients with severe systemic disease experiencing hemodynamic difficulties during non-cardiac surgery. In this single-centre trial (n = 31) of patients undergoing predominantly abdominal or orthopaedic surgery, 9 of the 20 standard TEE views were used to assess the cause for the hemodynamic instability [21•]. Rescue echocardiography not only provided a diagnosis but also changed pharmacological and fluid therapy as well as directed emergency secondary procedures such as pericardial drainage, percutaneous coronary intervention and pulmonary thrombectomy. TEE may also have a role in determining the cause of hemodynamic instability in trauma patients unresponsive to fluid resuscitation . TEE helps to diagnose pre-existing cardiac problems and traumatic thoracic injury but the risk of TEE-related viscus rupture potentiated by high gastric volumes or associated traumatic oesophageal injury must be considered.
Recognizing the increasing use of perioperative echocardiography, the recent consensus statement from the American Society of Echocardiography (ASE) and the Society of Cardiovascular Anesthesiologists (SCA) outlines the 11 basic TEE views necessary to perform a non-comprehensive examination in order to diagnose the cause of hemodynamic instability and guide therapeutic interventions [23••]. The appropriate views required for assessment of ventricular function, hypovolemia, basic valvular lesions, pulmonary embolism, venous air embolism, pericardial effusion, thoracic trauma and simple congenital heart disease in adults are well described.
TEE is used to diagnose hypovolemia and ischemic myocardium following vascular surgery. Both left ventricular systolic and diastolic dysfunction were significant predictors of postoperative cardiovascular events . TEE provides a fast, precise and portable diagnostic tool in emergency vascular surgery for aortic dissection and disruption. In aortic dissection needing endovascular aortic repair, TEE has been used to identify the true lumen, the landing zone, guide the deployment of the stent and diagnose endoleaks .
TEE in Liver Transplantation Surgery
TEE in high-risk non-cardiac surgery such as liver transplantation is increasingly performed in high-volume transplant centres [26, 27]. A limited upper oesophageal TEE examination is useful in managing fluid therapy, monitoring myocardial function and identifying intraoperative complications, including heart failure, even in the setting of distal oesophageal pathology . Intraoperatively, the effects of major phases of the surgical procedure (dissection phase, venovenous bypass, anhepatic phase and reperfusion phase) can be monitored by TEE .
Cardiac disease is the leading cause of maternal mortality in developing countries. The use of TEE as a monitoring tool in acute, severe hemodynamic instability in the peripartum period has been limited to case reports . TEE has been used in high-risk obstetric patients with pulmonary hypertension or congenital heart disease or in the diagnosis of massive amniotic fluid embolism .
3-Dimensional Transesophageal Echocardiography
2D TEE has been the backbone of echocardiographic imaging but one of the main limitations has been the inability to visualize the entire structure. For example, various methodologies to image the mitral valve do not take into account the physiological and pathological variations in anatomy. In fact, haptic knowledge of the TEE probe adjustments needed to acquire an image was found to be crucial in identifying the mitral scallops accurately .
Although 3D technology has been around for over a couple of decades, recent advances in technology such as multilinear probes, volumetric dataset acquisition and offline analysis have enhanced our understanding of the heart . 3D TEE has made it easier to interrogate, interpret and understand complex structures such as the mitral valve and right ventricle. This in-depth knowledge of pathophysiological anatomy is crucial for success in surgical techniques especially the minimally invasive and transcatheter approaches. Live 3D TEE has helped to direct these interventions by intuitively guiding these procedures . Use of augmented reality in ultrasound to guide interventions is likely to improve this experience in the future .
3D TEE of the Mitral Valve
The mitral annulus (MA) is a nonplanar, saddle-shaped, hyperbolic paraboloid fibrous ring [36••]. Comprehensive 3D analysis of the mitral valve (MV) using customized software has been used to generate high-resolution, consistent 3D models with very little inter-operator and intra-operator variability . Evaluation of the complex morphology and dynamics of the MV using different types of computational, geometrical and biomechanical models is likely to lead to a better understanding of the MV . In mitral or ventricular pathology, the MA may be dilated, deformed or flattened causing a loss of the saddle shape leading to inefficient contraction during systole and valvular incompetence [39, 40].
3D TEE of the Right Heart
Right heart dysfunction in the perioperative period is associated with poor outcomes. Numerous publications have described the views on the echocardiographic evaluation of the right heart [41, 42, 43]. 3D TEE has helped in understanding the irregular, complex anatomy of the right heart by visualizing the entire RV and eradicating geometric assumptions. 3D TEE datasets on patients undergoing cardiac surgery offer an emerging and validated approach to assess RV stroke volume [44•]. Customized software creates a surface-rendering cast of the RV and helps measure end-diastolic and end-systolic volumes as well as segmental analyses of the inlet, apex and outflow segments. Measuring the tricuspid annular area using 3D planimetry has been shown to be more accurate than the conventional linear ellipse method .
3D TEE in Congenital Heart Disease
Congential heart disease (CHD) is recognized for its complex intra-cardiac anatomy and intricate 3-dimensional correlations . Careful acquisition, expert evaluation and interpretation of multiple images are needed when using 2D imaging . 3D imaging not only simplifies this process but also provides additional value and improved image quality [48, 49]. The en face views using 3D technology provide a unique perspective of the complex morphology and pathophysiology of congenital defects . Multiplanar reconstruction (MPR) provides access to an unlimited number of 2D echocardiographic planes. 3D echocardiographic measurement of ventricular volumetrics has been shown to have good correlation with Magnetic resonance imaging [51, 52]. High-quality 3D TEE is increasingly being used for diagnosis, assessment and guidance of transcatheter interventions with good effect.
TEE for Transcatheter Interventions (TCI)
Transcatheter Aortic Valve Implantation
TEE is useful in patient selection, choice of procedure and prosthesis, monitoring during the procedure as well as detection of complications. TEE helps evaluate LVOT and aortic root anatomy, aortic annular size, valve opening, the number, mobility and thickness of cusps, extent and distribution of calcification, distance from the aortic annulus to coronary ostia and aortic atheroma [53••]. There is no consensus regarding the gold standard imaging technique for annular sizing but TEE measurements correlate well with TTE . The depth perspective of 3D TEE has aided us to understand the anatomy of the annulus and to visualize the deployment of the prosthesis.
Percutaneous Mitral Valve Intervention
Percutaneous mitral valve intervention is used to repair the mitral valve in high-risk patients. Echocardiography is necessary to assess the functional anatomy, the mechanism of mitral regurgitation (MR) and guide the procedure. The different techniques include indirect and direct annuloplasty, leaflet repair and ventricular remodelling [53••]. In the percutaneous edge-to-edge repair using Mitraclip, a coapting surface length >2 mm, coaptation depth of <11 mm, flail height of ≤10 mm and flail width of ≤15 mm are necessary to achieve optimum results . 3D TEE is invaluable during all stages of the procedure including trans-septal catheterization, positioning and orienting the clip above the regurgitant orifice and grasping of the edges to achieve a double-orifice mitral valve.
Paravalvular Regurgitation (PVR)
Improvements in Technology
A miniaturized, single-use, hemodynamic TEE probe (ImaCor, Garden City, NY, USA) has been used as a point-of-care device to aid placement of cannulae, assessment of volume status, hemodynamics and valvular pathophysiology. The probe can be left in the oesophagus for up to 72 h for a focused, intermittent, hemodynamic assessment. It has been used in hemodynamically unstable postoperative cardiac surgical patients, liver transplantation and weaning from ECMO [58, 59].
Assessment of ventricular function using the traditional volumetric and linear measures of left ventricular systolic function has limitations, and techniques to quantify myocardial deformation have been developed . Speckle-tracking echocardiography (STE) is a more objective method which analyses myocardial motion by tracking blocks of 20–40 pixels containing stable echo patterns (speckles) within an ultrasonic window in consecutive frames. An image-processing algorithm tracks these speckles and provides angle-independent sequences of tissue motion and deformation . Several parameters including strain, strain rate, torsional deformation and twist can be measured .
A recent review of the use of STE during cardiac surgery looked at the ability of STE to assess ventricular function intraoperatively . Strain analysis has minimized inter- and intraobserver variability in detection of contractile dysfunction compared to traditional wall motion scoring systems . Strain measurements obtained using TEE also correlate well with TTE measurements; however, no reference values exist for equivalence [64, 65].
Education and Training
There have been several published guidelines in recent years by various organizations on training, performance and appropriateness of TEE [1, 6, 53••]. These guidelines are likely to standardize training, techniques, image acquisition and research protocols. Recent ASE guidelines for performing a comprehensive TEE examination require 28 imaging views with a suggested protocol of image acquisition [66••]. They also underline the importance of knowledge, formal guidelines and training pathways to achieve competency in basic TEE.
Simulation-Based Medical Education
Training in image acquisition needs skills to deal with a complex interface among the echocardiographer, the machine and the patient. In-depth knowledge of cardiac anatomy, physiology, physics of ultrasound and repetitive, hands-on experience is essential to gain proficiency in image acquisition. Training in echocardiography is often limited by lack of structured training opportunities and sufficient regular training time [67•]. Simulation-based medical education has been shown to minimize patient risks, discomfort and potential distraction in high-stress clinical environments [68, 69]. The echocardiographic simulators available include online software programmes or mannequin-based echocardiographic (TEE & TTE) simulators [70•].
The online software programmes are usually free web-based simulation programmes that help in image orientation . The virtual TEE probe is manipulated by either mouse or keyboard controls. The scan plane of the probe slices through the virtual heart model or computerized tomographic datasets and the TEE views are seen on the interface. The main disadvantage of these online software programmes is the lack of actual tactile sensation that comes with the handling of a TEE/TTE probe.
The mannequin-based simulators contain a life-sized mannequin with a model heart or a virtual heart placed within an electromagnetic field. The motion sensor inside the echocardiographic probe tip determines the position and movement of the probe within that electromagnetic field. This position of the probe tip is then used by simulation software to generate 2D echocardiographic images from the virtual heart . The software controls allow for manipulation of the images similar to the TEE machine. Normal anatomical and pathological software modules are available . Moreover, the haptic experience gained by handling and manipulation of the probe is a major advantage of these simulators. One of the main disadvantages is the excessive cost of echocardiographic simulators.
Image acquisition in echocardiography require small, multiple, instinctive probe adjustments which need considerable manual dexterity. Metrics are defined as a set of tools to track and objectively quantify repeat performances of a predefined action . A unique echocardiographic metrics system, Vimedix simulation system (CAE Healthcare Inc., Montreal, Canada) can now measure the time taken to acquire an image (time metrics), track the probe movements made in 3D space and compare the acquired image to the ideal image (motion metrics). Also, the recorded image can be compared in quality with other operators and experts (observer metrics). Kinematic analysis of probe motion has been used to track the motion of the probe in the x, y and z axes in relation to a virtual heart model . Metrics can be used for performance evaluation and research purposes, and is likely to transform simulation-based training in echocardiography. 
Safety of TEE
Although TEE procedures have been shown to be relatively safe with a low incidence of serious gastroesophageal injury (0.03–0.09 %), TEE-related complications are commonly associated with medicolegal litigation . This is partly due to the devastating morbidity and mortality (10–56 %) caused by complications such as oesophageal perforation and partly due to the delay in diagnosis and treatment of this insidious complication [78, 79]. Gastroesophageal pathology, distorted anatomy and resistance to probe insertion are major risk factors . More importantly, oesophageal perforation can even occur in patients without major risk factors or after an uncomplicated TEE procedure. The risk factors in these patients are elderly age, female sex, small stature and TEE in the operative setting . Listing oesophageal perforation as a specific risk in the informed consent may limit medicolegal liability . Major bleeding complications after TEE with an incidence of 0.02–1.0 % may occur secondary to direct trauma or disruption of friable tissues (e.g. oesophageal varices, oesophageal tumours) . Oesophageal varices, however, are not an absolute contraindication to TEE if correct precautions are taken . Rigid laryngoscopy can reduce the incidence of odynophagia and oropharyngeal mucosal laceration in patients when blind insertion of the TEE probe has proved difficult .
Advances in the future are likely to include improvements in miniaturization, closed-loop systems, customized quantification software, augmented reality, integrated multimodality imaging and telediagnosis. Ageing populations, increased incidence of obesity, type-2 diabetes and cardiovascular diseases are likely to increase the use of echocardiography. High-quality TEE in minimally invasive surgery, transcatheter interventions and CHD will be in great demand as these novel indications will continue to pose new challenges.
Integrated, small, robust, inexpensive, high-quality imaging consoles and miniaturized probes with the capacity to provide excellent images are likely to improve bed-side, clinical decision making. Refinements in transducer technology will make high-resolution 3D TEE available across the spectrum of patient sizes .
The exponential growth in technological innovation together with an ever-improving understanding of human physiology is likely to herald significant changes in the future. Innovations in medical technology, microprocessing power, informatics and systems automation will no doubt boost these advances. For example, using battery or solar power as an energy source for ultrasound has seen an upsurge in the identification of heart disease in a low-infrastructure, developing world environment .
Standardization of technique, quantification and even equipment according to guidelines set by august bodies will minimize errors, underperformance and aid training of novices. Quantitative assessments will be used to reduce variance in interpretation.
TEE is a semi-invasive, portable, safe and readily available imaging modality which provides real-time, unique clinical information in the intraoperative setting. There has been an exponential growth in the use of TEE in surgical patients. However, there are no studies in which TEE has been randomized as an intervention to assess patient outcome. The lack of good quality evidence has not dampened the enthusiasm with which the modality has been embraced by the medical community. Indeed, given its wide-spread use, it would probably be unethical and impractical to conduct a blinded randomized controlled trial. A systematic approach to image acquisition and interpretation, improvements in technology, miniaturization and an increase in minimally invasive procedures is likely to see the spread of perioperative TEE in the future.