, Volume 2, Issue 2, pp 75-83
Date: 14 Mar 2014

Zebrafish Models of Biliary Atresia and Other Infantile Cholestatic Diseases

Abstract

Zebrafish are a powerful tool for the study of diseases that appear during development. Over the past decade, several zebrafish models of diseases that affect the developing liver in infants have been generated, including models of the most common identifiable cause of neonatal cholestasis, biliary atresia (BA). While none of these models exactly duplicate the disorder, studies on the zebrafish models have uncovered potentially important features of BA such as an importance of epigenetic changes and an association with specific mutations. In addition, other models replicate other cholestatic disorders, and there are zebrafish models of other pediatric liver diseases as well. Continued efforts with these models, and future models that take advantage of emerging technologies, will uncover additional facets of disease pathogenesis and may identify novel, more effective therapies.