, 1:1009
Date: 17 Sep 2012

Pertussis immunity wanes in the 5 years after DTaP vaccination

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medwireNews: The risk for pertussis infection in children who receive the combined diphtheria, tetanus, and acellular pertussis (DTaP) vaccine increases by an average of 42% per year after the last dose, a US study shows.

The Californian cohort included a period in 2010 marked by a pertussis outbreak in the state and Nicola Klein (Kaiser Permanente, Oakland, California) and colleagues suggest that “waning efficacy among school-age children played a key role in both allowing and sustaining the outbreak.”

In the early 1990s, the USA started to make the transition from whole-cell pertussis vaccines to DTaP. Receipt of five doses of DTaP is mandatory for school entry in many states, including California, with the fifth dose usually administered in children between 4 and 6 years of age.

However, pertussis outbreaks still occur every 3 to 5 years, with an increase in the peak incidence with each successive outbreak.

To investigate, Klein et al performed a case-control study in children aged 4 to ...