Infection

, Volume 28, Issue 5, pp 326–328

Congenital Skin Lesions Caused by Intrauterine Infection with Coxsackievirus B3

  • A. Sauerbrei
  • B. Glück
  • K. Jung
  • H. Bittrich
  • P. Wutzler
Case reports

DOI: 10.1007/s150100070029

Cite this article as:
Sauerbrei, A., Glück, B., Jung, K. et al. Infection (2000) 28: 326. doi:10.1007/s150100070029
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Summary

Background: Serious neonatal coxsackievirus infections transplacentally acquired in late pregnancy involve primarily the central nervous system, heart, liver and rarely the skin.

Patients and Methods: A boy born with a disseminated papulovesicular, nodular, bullous and necrotic ulcerated rash at 39 weeks gestational age developed pneumonia, carditis and hepatitis during the first days after birth. Molecular biological and serological methods were used for virological diagnosis.

Results: Coxsackievirus B3 (CVB3) was found in throat swabs and/or feces of the neonate and his mother. In addition, there was serological evidence of intrauterine infection.

Conclusion: Intrauterine transmission of CVB3 during late pregnancy may lead to varicella-like congenital skin lesions.

Key Words Coxsackievirus B3 Intrauterine infection Neonatal disease Congenital skin lesions Virological diagnosis 

Copyright information

© Urban & Vogel Medien und Medizin Verlagsgesellschaft 2000

Authors and Affiliations

  • A. Sauerbrei
    • 1
  • B. Glück
    • 2
  • K. Jung
    • 3
  • H. Bittrich
    • 4
  • P. Wutzler
    • 1
  1. 1.Institute for Antiviral Chemotherapy, Friedrich Schiller University of Jena, Nordhäuser Str. 78, D-99089 Erfurt, Germany; Phone: (+49/361) 7411-314, Fax: -114; e-mail: sauerbre@zmkh.ef.uni-jena.deDE
  2. 2.Institute of Virology, Friedrich Schiller University of Jena, Winzerlaer Str. 10, D-07745 Jena, GermanyDE
  3. 3.Skin Disease Clinic, Klinikum Erfurt GmbH, Arnstädter Str. 34, D-99096 Erfurt, GermanyDE
  4. 4.Pediatric Clinic, Klinikum Erfurt GmbH, Am Schwemmbach 32a, D-99099 Erfurt, GermanyDE

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