Infection

, Volume 27, Issue 6, pp 331–334

Negative Predictors of Survival in HIV-Infected Patients with Culture-Confirmed Pulmonary Tuberculosis

  • F. Palmieri
  • A.M. Pelicelli
  • E. Girardi
  • A.P. De Felici
  • P. De Mori
  • N. Petrosillo
  • G. Ippolito
Clinical and Epidemiological Studies

DOI: 10.1007/s150100050038

Cite this article as:
Palmieri, F., Pelicelli, A., Girardi, E. et al. Infection (1999) 27: 331. doi:10.1007/s150100050038

Summary

We performed a retrospective study based on chart review of 118 HIV-infected patients with culture-confirmed pulmonary TB, in which M. tuberculosis isolates were tested for drug susceptibility.

Patients were enrolled in the period January 1987 to December 1996 and followed until September 1997.

The median survival for the entire cohort was 15.2 months with a 1-year survival rate of 57%. Prior AIDS-defining illness, low CD4 count (< 200/mm3), not having received antituberculous therapy with at least two drugs to which M. tuberculosis was susceptible in vitro, starting within four weeks of diagnosis, treatment duration of less than three weeks and multidrug resistant tuberculosis were each independently associated with decreased survival in multivariate analysis.

Key words TuberculosisHIV infectionsDrug-resistant tuberculosisPrognosisSurvival

Copyright information

© Urban & Vogel Medien und Medizin Verlagsgesellschaft 1999

Authors and Affiliations

  • F. Palmieri
    • 1
  • A.M. Pelicelli
    • 1
  • E. Girardi
    • 2
  • A.P. De Felici
    • 3
  • P. De Mori
    • 3
  • N. Petrosillo
    • 1
  • G. Ippolito
    • 2
  1. 1.II Divisione IRCCS “L. Spallanzani”, Via Portuense 292, I-00149 Rome, Italy, Phone: +39-655170294, Fax: +39-65594224, e-mail: f.palmieri@flashnet.itIT
  2. 2.Centro di Riferimento AIDS – Servizio di Epidemiologia delle Malattie Infettive, Via Portuense, 292, I-00149 Rome, ItalyIT
  3. 3.Laboratorio di Microbiologica, IRCCS “L. Spallanzani”, Via Portuense 292, I-00149 Rome, ItalyIT