Infection

, Volume 41, Issue 3, pp 723–726

Cerebral Scedosporium apiospermum infection presenting with intestinal manifestations

  • D. Lin
  • K. Qurat-Ul-Ain
  • S. Lai
  • D. M. Musher
  • R. Hamill
Case Report

DOI: 10.1007/s15010-013-0429-8

Cite this article as:
Lin, D., Qurat-Ul-Ain, K., Lai, S. et al. Infection (2013) 41: 723. doi:10.1007/s15010-013-0429-8

Abstract

We present a case of cerebral Scedosporium apiospermum infection presenting with intestinal manifestations in a 64-year-old male patient on immunosuppression for orthotopic liver transplantation. At admission, the patient’s chief complaint was chronic watery diarrhea and he was found to have colonic ulcers on endoscopy. His hospital course was complicated by a tonic–clonic seizure caused by a left frontal brain abscess, with the causative agent being identified by culture. He was treated with lobectomy, high-dose intravenous voriconazole, and liposomal amphotericin with clinical, endoscopic, and histologic improvement. To our knowledge, S. apiospermum has not been previously described as a cause of colitis. The septate branching appearance of the Scedosporium species is similar to the more common Aspergillus species. This case of gastrointestinal Scedosporium brings into question previously reported cases of isolated gastrointestinal aspergillosis diagnosed by histopathology. Clinical suspicion for S. apiospermum must be maintained in immunosuppressed patients presenting with neurologic and gastrointestinal symptoms.

Keywords

Colitis Brain abscess Immunocompromised Scedosporium apiospermum Fungal Hyphae Aspergillus Aspergillosis 

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • D. Lin
    • 1
  • K. Qurat-Ul-Ain
    • 1
  • S. Lai
    • 1
    • 4
  • D. M. Musher
    • 1
    • 2
    • 3
  • R. Hamill
    • 1
    • 3
  1. 1.Department of MedicineBaylor College of MedicineHoustonUSA
  2. 2.Department of Molecular Virology and MicrobiologyBaylor College of MedicineHoustonUSA
  3. 3.Medical Care Line, Infectious Disease SectionMichael E. DeBakey Veterans Affairs Medical CenterHoustonUSA
  4. 4.Medical Care Line, Pathology SectionMichael E. DeBakey Veterans Affairs Medical CenterHoustonUSA

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