, Volume 41, Issue 3, pp 735-736
Date: 17 Nov 2012

Testicular involvement during Toscana virus infection: an unusual manifestation?

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Letter to the Editor:

Toscana virus (TOSV), transmitted by the Phlebotomus genera, is the most common cause of viral meningitis in the Mediterranean area during summer [1]. Generally, the disease is benign and self-limited, although severe complications such as encephalitis and cerebral ischemia are described [2]. Asymptomatic infections and clinical manifestations in the absence of central nervous system involvement are also documented [3, 4]. We describe an unusual manifestation of TOSV infection in a patient residing in central Italy (Siena district, Tuscany). On 4 September 2012, a 29-year-old previously healthy man was admitted to hospital for fever and severe headache lasting 3 days; testicular pain and diarrhea were also reported. On admission, the patient was suffering and alert with an axillary temperature of 37.3 °C, pulse rate of 80 beats/min, respiratory rate of 20 breaths/min, and blood pressure of 110/80 mmHg. Physical examination revealed signs of meningeal irritation, in