Infection

, Volume 41, Issue 2, pp 321–328

Comparison of polymyxin B with other antimicrobials in the treatment of ventilator-associated pneumonia and tracheobronchitis caused by Pseudomonas aeruginosa or Acinetobacter baumannii

Authors

  • M. H. Rigatto
    • Infectious Diseases ServiceHospital São Lucas da Pontifícia Universidade Católica do Rio Grande do Sul
  • V. B. Ribeiro
    • Laboratory of MicrobiologyHospital de Clínicas de Porto Alegre
  • D. Konzen
    • School of MedicinePontifícia Universidade Católica do Rio Grande do Sul
    • Infectious Diseases ServiceHospital de Clínicas de Porto Alegre
Clinical and Epidemiological Study

DOI: 10.1007/s15010-012-0349-z

Cite this article as:
Rigatto, M.H., Ribeiro, V.B., Konzen, D. et al. Infection (2013) 41: 321. doi:10.1007/s15010-012-0349-z

Abstract

Purpose

This study was designed to compare the efficacy of polymyxin B with other antimicrobials in the treatment of ventilator-associated pneumonia (VAP) and tracheobronchitis (VAT) by Pseudomonas aeruginosa or Acinetobacter baumannii.

Methods

A prospective cohort study was performed. Patients >18 years of age with the diagnosis of VAP or VAT who received appropriate therapy for >48 h were analyzed. The primary outcome was 30-day mortality. Clinical covariates were assessed and compared between the groups.

Results

A total of 67 episodes were analyzed: 45 (67 %) treated with polymyxin B and 22 (33 %) with comparators. The crude 30-day mortality was 53 % (24 of 45) in the polymyxin B group and 27 % (6 of 22) in the comparator group (P = 0.08). Multivariable analysis using Cox regression models indicated that polymyxin B treatment was independently associated with increased mortality.

Conclusions

Polymyxin B treatment in the currently recommended dosage may be inferior to other drugs in the treatment of VAP and VAT caused by organisms tested as susceptible in vitro to this agent.

Keywords

Pseudomonas aeruginosa Acinetobacter baumannii Polymyxin B Colistin Ventilator-associated pneumonia

Copyright information

© Springer-Verlag Berlin Heidelberg 2012