Infection

, Volume 36, Issue 2, pp 147–152

Evidence of a TH1-Shift of Local Vaginal Inflammatory Response During Bacterial Vaginosis

  • G. Anton
  • J. Rid
  • I. Mylonas
  • K. Friese
  • E.-R. Weissenbacher
Clinical and Epidemiological Study

DOI: 10.1007/s15010-007-7152-2

Cite this article as:
Anton, G., Rid, J., Mylonas, I. et al. Infection (2008) 36: 147. doi:10.1007/s15010-007-7152-2
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Abstract

Objective:

To determine the levels of pro-inflammatory and anti-inflammatory cytokines in the vagina of healthy women and in bacterial vaginosis (BV) patients.

Methods:

Interleukin (IL)-1α, 1β, 5 and 10 were analyzed by ELISA in vaginal wash fluids from 50 non-pregnant patients with BV and 112 healthy women.

Results:

Levels of IL-1β were higher and those of IL-10 lower in BV-patients than in healthy women. There was a tendency towards higher levels of IL-1α in BV patients, but these data were not statistically significant.

Conclusion:

We found evidence for a shift towards a TH1-dominated vaginal cytokine profile in the pathogenesis of BV. Levels of a TH1-cytokine were elevated and those of a TH2-cytokine lowered in BV-patients as compared to healthy controls. This points to a vaginal TH1-response during BV and to the importance of cell-mediated immunity in local vaginal infections.

Copyright information

© Urban & Vogel München 2008

Authors and Affiliations

  • G. Anton
    • 1
  • J. Rid
    • 1
  • I. Mylonas
    • 2
    • 3
  • K. Friese
    • 1
    • 2
  • E.-R. Weissenbacher
    • 1
  1. 1.Dept. of Obstetrics and Gynecology, Klinikum GroßhadernLudwig Maximilian UniversityMunichGermany
  2. 2.1st Dept. of Obstetrics and Gynecology, Klinikum InnenstadtLudwig Maximilian UniversityMunichGermany
  3. 3.1. FrauenklinikMunichGermany