Seroepidemiology and Molecular Characterization of Hepatitis E Virus in Jilin, China
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In order to develop region-specific diagnostic assays and prevent hepatitis E virus (HEV), it is essential to understand epidemiology and genotypic variation within different populations. However, the epidemiological data of HEV infections in Jilin is shortage.
The seroepidemiological study was conducted by enzyme-linked immunosorbent assay, and the conserved genomic sequences of open reading frame 2 (348 bp) was detected using reverse transcription-PCR.
Overall, 1,289 serum samples were positive to HEV-specific immunoglobulin G (IgG), and 180 serum samples were positive to HEV-specific immunoglobulin M (IgM). The seroprevalence of HEV-specific IgG was 26.3%, 27.9%, 25.3%, 32.7% in 2003, 2004, 2005, 2006, respectively. Acute HEV infection mainly occurred in male, people aged from 20 to 69 were more susceptible to infection, and cases with IgM anti-HEV reaction mainly occurred from July to November. HEV RNA was detectable in the serum samples or stool suspension of 15 patients with HEV-specific IgM, and all of these belonged to genotype IV.
Our results indicate that HEV is widely spread in Jilin and confined to genotype IV.
- Seroepidemiology and Molecular Characterization of Hepatitis E Virus in Jilin, China
Volume 36, Issue 2 , pp 140-146
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- Urban & Vogel
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- 1. Genetic Engineering Laboratory, Academy of Military Medical Sciences, 1068 Qinglong Road, Changchun, 130062, People's Republic of China
- 3. The First Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun, People's Republic of China
- 4. College of Animal Science and Technology, Shihezi University, Shihezi, People's Republic of China
- 2. China-Japan Union Hospital of Jilin University, Changchun, People's Republic of China