Infection

, Volume 36, Issue 1, pp 41–45

Risk Factors for Community-Acquired Urinary Tract Infection Due to Quinolone-Resistant E. coli

Clinical and Epidemiological Study

DOI: 10.1007/s15010-007-7083-y

Cite this article as:
Colodner, R., Kometiani, I., Chazan, B. et al. Infection (2008) 36: 41. doi:10.1007/s15010-007-7083-y

Abstract

Background:

Resistance to fluoroquinolone drugs is emerging among E. coli causing community acquired urinary tract infections (COMA-UTI).

Objectives:

To evaluate demographic and clinical risk factors associated with COMA-UTI due to quinolone-resistant E. coli (QREc).

Methods:

In this case-control study, clinical and demographic data from 300 COMA-UTI due to E. coli (including 150 QREc) were analyzed.

Results:

By univariate analysis QREc was associated to males, older patients, nursing home residents, functionally dependent, dementia, diabetes, cardiovascular diseases, immunosupression, nephrolithiasis, recurrent UTI, invasive procedures, hospitalization, and antibiotic use within previous 6 months. By multivariate analysis, use of ciprofloxacin (OR 20.6 [CI 2.3–179.2], p = 0.006) or ofloxacin (OR 7.5 [CI 2.9–19.4], p < 0.0001), previous invasive procedure (OR 6.6 [CI 3.0–14.7], p < 0.0001), recurrent UTI (OR 4.7 [CI 2.3–9.3], p < 0.0001), and previous hospitalization (OR 2.9 [CI 1.4–6], p = 0.003) were identified as independent risk factors for COMA-UTI due to QREc.

Conclusion:

In patients with one or more of the risk factors identified here, the empiric use of quinolones should be reconsidered.

Copyright information

© Urban & Vogel München 2008

Authors and Affiliations

  • R. Colodner
    • 1
  • I. Kometiani
    • 2
  • B. Chazan
    • 3
    • 4
  • R. Raz
    • 3
    • 5
  1. 1.Clinical Microbiology LaboratoryHa'Emek Medical CenterAfulaIsrael
  2. 2.Internal Medicine AHa'Emek Medical CenterAfulaIsrael
  3. 3.Infectious Diseases UnitHa'Emek Medical CenterAfulaIsrael
  4. 4.Family MedicineNorth Branch of Ben Gurion UniversityAfulaIsrael
  5. 5.Rappaport School of Medicine, TechnionHaifaIsrael