Infection

, Volume 36, Issue 1, pp 46–53

Recent Acquired STD and the Use of HAART in the Italian Cohort of Naive for Antiretrovirals (I.Co.N.A): Analysis of the Incidence of Newly Acquired Hepatitis B Infection and Syphilis

  • P. Cicconi
  • A. Cozzi-lepri
  • G. Orlando
  • A. Matteelli
  • E. Girardi
  • A. Degli Esposti
  • C. Moioli
  • G. Rizzardini
  • A. Chiodera
  • G. Ballardini
  • C. Tincati
  • A. d'Arminio Monforte
  • for the I.Co.N.A. Study Group
Clinical and Epidemiological Study

DOI: 10.1007/s15010-007-6300-z

Cite this article as:
Cicconi, P., Cozzi-lepri, A., Orlando, G. et al. Infection (2008) 36: 46. doi:10.1007/s15010-007-6300-z

Abstract

Objective:

To estimate the incidence of newly acquired syphilis (n-syphilis) and hepatitis B infection (n-hepatitis B) in I.Co.N.A. and to evaluate the impact of HAART, calendar date and risk group.

Methods:

Cohort study: Incidence was calculated by person–years analyses. Poisson regression was used for the multivariate model.

Results:

The rate of n-syphilis was 23.4/1,000 PYFU and it increased over time; HIV transmission risk was the most important predictor: men who have sex with men (MSM) had a considerable higher risk (RR 5.92, 95% CI 2.95–12.13 vs IDU/exIDU, p < 0.0001). The rate of n-hepatitis B was 12.2/1,000 PYFU; it declined in recent years and halved per 10 years age. Patients with HIV-RNA < 500 copies/ml had a 60% reduced risk of n-hepatitis B if they were treated with HAART compared with not treated individuals.

Conclusions:

In our population, the use of HAART was not associated with a higher risk of newly acquired sexually transmitted diseases (STD). Suppressive HAART was associated with a lower risk of HbsAg seroconversion. Incidence of n-hepatitis B has recently been declining possibly due to herd immunity provided by vaccination policies. The risk of acquiring n-syphilis has increased over time and it is higher in the population of MSM compared with other categories of HIV exposure.

Copyright information

© Urban & Vogel München 2008

Authors and Affiliations

  • P. Cicconi
    • 1
  • A. Cozzi-lepri
    • 2
  • G. Orlando
    • 3
  • A. Matteelli
    • 4
  • E. Girardi
    • 5
  • A. Degli Esposti
    • 6
  • C. Moioli
    • 7
  • G. Rizzardini
    • 8
  • A. Chiodera
    • 9
  • G. Ballardini
    • 10
  • C. Tincati
    • 1
  • A. d'Arminio Monforte
    • 1
  • for the I.Co.N.A. Study Group
  1. 1.Clinic of Infectious and Tropical Diseases, Dept. of Medicine Surgery and DentistryUniversity of Milan, San Paolo HospitalMilanItaly
  2. 2.Dept. of Primary Care and Population SciencesRoyal Free and University College Medical SchoolLondonUK
  3. 3.II Div. Infectious DiseasesH. Luigi SaccoMilanItaly
  4. 4.Clinic of Infectious and Tropical DiseasesUniversity of BresciaBresciaItaly
  5. 5.INMI L SpallanzaniRomeItaly
  6. 6.Dept. of Infectious DiseasesH S. AnnunziataFlorenceItaly
  7. 7.Dept. Infectious DiseasesH. NiguardaMilanItaly
  8. 8.I Div Infectious DiseasesH. Luigi SaccoMilanItaly
  9. 9.Dept. of Infectious DiseasesH. MacerataMacerataItaly
  10. 10.Dept. of Infectious DiseasesH S. Maria Delle CrociRavennaItaly