, Volume 35, Issue 4, pp 212–218

Clinical Features of Liver Involvement in Adult Patients with Listeriosis. Review of the Literature


    • Dept. of Medical Microbiology and Infection ControlVU University Medical Center
    • Dept. of Medical Microbiology and Infection ControlJeroen Bosch Medical Centre
  • P. M. Schneeberger
    • Dept. of Medical Microbiology and Infection ControlJeroen Bosch Medical Centre
  • P. van den Dries
    • Dept. of Internal MedicineBernhoven Medical Centre
  • J. P. H. Drenth
    • Dept. of Gastroenterology and HepatologyRadboud University Nijmegen Medical Centre

DOI: 10.1007/s15010-007-6006-2

Cite this article as:
Scholing, M., Schneeberger, P.M., van den Dries, P. et al. Infection (2007) 35: 212. doi:10.1007/s15010-007-6006-2


Clinical features of liver involvement due to Listeria monocytogenes infection in adults are rarely reported in literature. This is surprizing, regarding the current opinion that the portal system is extensively involved in the first stages of pathogenesis in invasive L. monocytogenes disease. A literature search in the PubMed and Embase database revealed 34 cases with clinical features of hepatic involvement due to listeriosis. We systematically analyzed all case reports with respect to clinical manifestations, treatment and outcome. In addition, we added clinical information on a patient diagnosed with a solitary liver abscess due to L. monocytogenes, who was seen at our institution. This review describes the different presentations of liver-involvement reported in listeriosis; solitary liver abscess, multiple liver abscesses and diffuse or granulomatous hepatitis. Distinction between these different forms of liver involvement is clinically relevant as they have a different outcome. We delve into the different pathogenic events leading to different forms of liver involvement. In addition, diagnostic modalities and possible treatments are reviewed.

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© Urban & Vogel München 2007