Infection

, Volume 35, Issue 1, pp 33–36

Improvement of Progressive Multifocal Leukoencephalopathy After Cidofovir Therapy in a Patient with a Destructive Polyarthritis

Authors

    • Service de Médecine Interne et Maladies InfectieusesHôpital Haut-Lévêque
  • E. Lazaro
    • Service de Médecine Interne et Maladies InfectieusesHôpital Haut-Lévêque
  • E. Ellie
    • Service de NeurologieCentre Hospitalier de la Côte Basque
  • S. Eimer
    • Laboratoire d’Anatomo-pathologieHôpital Pellegrin
  • F. Camou
    • Service de Médecine Interne et Maladies InfectieusesHôpital Haut-Lévêque
  • O. Caubet
    • Service de Médecine Interne et Maladies InfectieusesHôpital Haut-Lévêque
  • M. E. Lafon
    • Laboratoire de VirologieHôpital Pellegrin
  • H. Fleury
    • Laboratoire de VirologieHôpital Pellegrin
  • J. L. Pellegrin
    • Service de Médecine Interne et Maladies InfectieusesHôpital Haut-Lévêque
Case Report

DOI: 10.1007/s15010-006-5103-y

Cite this article as:
Viallard, J.F., Lazaro, E., Ellie, E. et al. Infection (2007) 35: 33. doi:10.1007/s15010-006-5103-y

Abstract

The human neurotropic JC virus (JCV) is responsible for progressive multifocal leukoencephalopathy (PML), an infectious demyelinating brain disease with major morbidity and mortality, usually refractory to treatment. We describe a PML in a 67-year-old woman with a destructive polyarthritis associated with anti-JO1 antibodies treated with corticosteroids. Although glucocorticoid therapy was maintained, administration of cidofovir improved the neurological condition. Our observation demonstrates the expanding clinical importance of JCV in systemic rheumatic diseases, particularly when immunosuppressive agents are used, and neurological symptoms or white matter changes on central nervous system imaging should arouse the suspicion of PML.

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© Urban & Vogel München 2007