Effect of resistant starch on HCl/ethanol-induced gastric injury in rats

  • Yu Qian
  • Guijie Li
  • Kai Zhu
  • Peng Sun
  • Xia Feng
  • Xin Zhao
Original Article Food Science/Microbiology

DOI: 10.1007/s13765-013-3143-4

Cite this article as:
Qian, Y., Li, G., Zhu, K. et al. J Korean Soc Appl Biol Chem (2013) 56: 613. doi:10.1007/s13765-013-3143-4
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Abstract

Three types of resistant starch (RS) products were purchased for the evaluation of gastric injury preventive effect in Sprague-Dawley rats. We used an animal model to check for gastric injury preventive activities of these RS products in vivo. RS3 reduced the levels of serum proinflammatory cytokines of IL-6 and TNF-α as compared to those of RS2 and RS4. The gastric secretion volumes from high to low order were control rats, RS2-treated rats, RS4-treated rats, RS3-treated rats, and normal rats, whereas pH levels of gastric juice showed the opposite trend. The gastric injury level was significantly decreased by RS, demonstrating its anti-inflammatory properties, with RS3 showing the best anti-inflammatory effect. Gastric tissues of RS3 group rats showed significantly decreased mRNA and protein expression levels of inflammation-related genes of iNOS, COX-2, TNF-α, and IL-1β compared with the control group, as shown by RT-PCR and Western blot analyses. These results suggest that RS shows a gastric injury preventive effect, with RS3 showing the best inhibitory effect on gastric injury.

Keywords

cytokine gastric injury gene expression resistant starch SD-rat 

Copyright information

© The Korean Society for Applied Biological Chemistry 2013

Authors and Affiliations

  • Yu Qian
    • 1
  • Guijie Li
    • 1
  • Kai Zhu
    • 1
  • Peng Sun
    • 1
  • Xia Feng
    • 1
  • Xin Zhao
    • 1
  1. 1.Department of Biological and Chemical EngineeringChongqing University of EducationChongqingPeople’s Republic of China

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