Acta Neurologica Belgica

, Volume 112, Issue 4, pp 327–333

Vitamin D and multiple sclerosis: a critical review and recommendations on treatment

Authors

  • Alireza Faridar
    • Department of NeurologyUniversity of California
  • Ghazaleh Eskandari
    • Brain and Spinal Injury Research CenterTehran University of Medical Sciences, Sina Hospital
  • Mohammad Ali Sahraian
    • SinaMS Research Center, Brain and Spinal Injury Research CenterTehran University of Medical Sciences
  • Alireza Minagar
    • Department of NeurologyLSU Health Sciences Center
    • Brain and Spinal Injury Research CenterTehran University of Medical Sciences, Sina Hospital
Review Article

DOI: 10.1007/s13760-012-0108-z

Cite this article as:
Faridar, A., Eskandari, G., Sahraian, M.A. et al. Acta Neurol Belg (2012) 112: 327. doi:10.1007/s13760-012-0108-z

Abstract

Multiple sclerosis (MS) is an immune-mediated and degenerative disease of nervous system, which affects mostly young adults. Vitamin D deficiency is a well-known environmental risk factor for MS and is considerable in terms of immediate clinical implications. In addition to its classical action on regulation of bone homeostasis, vitamin D may have a potent impact on cytokine profiles and neuro-inflammation. Given the immunomodulatory effects of vitamin D and its high rate of deficiency in MS patients, prescribing vitamin D is a remarkable issue in MS. The results from several experimental and clinical studies indicate that vitamin D supplementation may ameliorate the inflammation during the relapse phase and attenuate disease progression. We present the experimental and clinical studies, which assessed the effects of vitamin D on the pathophysiology, prevalence and management of MS. The authors also discuss current recommendations on prescription of this vitamin to MS patients.

Keywords

Vitamin DMultiple sclerosisDemyelinatingPrevention

Copyright information

© Belgian Neurological Society 2012