Original Article

Acta Neurologica Belgica

, Volume 113, Issue 1, pp 7-11

First online:

Circulating progenitor cells: a comparison of patients with glioblastoma or meningioma

  • George A. AlexiouAffiliated withDepartment of Neurosurgery, University Hospital of Ioannina Email author 
  • , George VartholomatosAffiliated withUnit of Molecular Biology, Haematology Laboratory, University Hospital of Ioannina
  • , Achilleas KaramoutsiosAffiliated withUnit of Molecular Biology, Haematology Laboratory, University Hospital of Ioannina
  • , Anna BatistatouAffiliated withDepartment of Pathology, University Hospital of Ioannina
  • , Athanasios P. KyritsisAffiliated withDepartment of Neurology, University Hospital of Ioannina
  • , Spyridon VoulgarisAffiliated withDepartment of Neurosurgery, University Hospital of Ioannina

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Abstract

Blood circulating endothelial cells and circulating hematopoietic progenitor cells (CPCs) are two cell populations that are thought to play important role in angiogenesis. In the present study, we investigated the role of CPCs in patients with brain tumors. We prospectively studied 19 brain tumor patients. Ten healthy individuals were used as controls. Variables that were analyzed included age, sex, Ki-67 index, symptom duration, tumor location, tumor size and preoperative Karnofsky performance status score (KPS). CPCs were determined as CD45dim/CD34+/CD133+ in the peripheral blood. Twelve patients had glioblastoma (GBM), 1 patient had a grade II glioma and 6 patients had meningioma. Brain tumor patients had significantly higher CPC levels compared to healthy volunteers. Patients with gliomas had significantly higher CPC levels than patients with meningiomas. In GBM patients no correlation was found between CPC levels and sex, age, Ki-67 index, tumor location, size and KPS. Patients with CPC levels lower than 1,743 cells/ml had a higher progression-free survival but the difference was not statistically significant. Glioma patients had higher CPC levels compared to patients with meningiomas. Larger studies are obviously needed to verify the role of CPC levels in patients with brain tumors.

Keywords

Circulating progenitor cells Glioma Meningioma