Original Paper

Journal of the Iranian Chemical Society

, Volume 10, Issue 5, pp 1001-1011

First online:

Novel 2,2′-bipyridine palladium(II) complexes with glycine derivatives: synthesis, characterization, cytotoxic assays and DNA-binding studies

  • Maryam SaeidifarAffiliated withNanotechnology and Advanced Materials Department, Materials and Energy Research Center Email author 
  • , Hassan Mansouri-TorshiziAffiliated withDepartment of Chemistry, University of Sistan and Baluchestan
  • , Adele DivsalarAffiliated withDepartment of Biological Sciences, Tarbiat Moallem University
  • , Ali Akbar SabouryAffiliated withInstitute of Biochemistry and Biophysics, University of Tehran

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Abstract

The two water-soluble designed palladium(II) complexes, [Pd(bpy)(pip-Ac)]NO3 and [Pd(bpy)(mor-Ac)]NO3, (where bpy is 2,2′-bipyridine, pip-Ac is 1-piperidineacetato and mor-Ac is 4-morpholineacetato) have been synthesized and characterized by elemental analyses, molar conductivity measurements and spectroscopic methods (FT-IR, 1H NMR, UV–Vis). The complexes have been tested for in vitro cytotoxic activity against human breast cancer cell line, T47D. The binding of these complexes with DNA has been investigated by absorption spectroscopy, fluorescence titration spectra, EB displacement and gel chromatography. The results suggest that the complexes can bind to DNA cooperatively through a static mechanism at low concentrations (~0.57 μM). The thermodynamic parameters indicated that the van der Waals and hydrogen binding might play a major role in the interaction of these complexes with DNA.

Keywords

DNA-binding Pd(II) complex 1-piperidineacetate 4-morpholinoacetate Cytotoxicity