Obesity Treatment (A Sharma, Section Editor)

Current Obesity Reports

, Volume 2, Issue 2, pp 120-127

First online:

Metabolic Effects of Bariatric Surgery: A Focus on Inflammation and Diabetic Kidney Disease

  • K. J. NeffAffiliated withDepartment of Experimental Pathology, UCD Conway Institute, School of Medicine and Medical Science, University College Dublin
  • , C. W. le RouxAffiliated withDepartment of Experimental Pathology, UCD Conway Institute, School of Medicine and Medical Science, University College Dublin Email author 

Abstract

Obesity is associated with metabolic dysfunction, including a positive energy balance, increased insulin resistance, dyslipidemia, hypertension and inflammation. Bariatric surgery is an effective treatment of many of the metabolic defects associated with obesity. In this review, we outline the effect of bariatric surgery on energy balance, glucose homeostasis, blood pressure control and lipid metabolism. We also examine the effect of bariatric surgery on inflammation, and in particular renal inflammation, and detail the evidence for the mechanisms underlying these effects.

Keywords

Bariatric surgery Metabolic disease Inflammation Insulin resistance Diabetic kidney disease Obesity