Genetic Epidemiology of Psoriasis
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- Gupta, R., Debbaneh, M.G. & Liao, W. Curr Derm Rep (2014) 3: 61. doi:10.1007/s13671-013-0066-6
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Psoriasis is a chronic, inflammatory, immune-mediated skin condition with a prevalence of 0–11.8 % across the world. It is associated with a number of cardiovascular, metabolic, and autoimmune disease comorbidities. Psoriasis is a multifactorial disorder, influenced by both genetic and environmental factors. Its genetic basis has long been established through twin studies and familial clustering. The association of psoriasis with the HLA-Cw6 allele has been shown in many studies. Recent genome-wide association studies have identified a large number of other genes associated with psoriasis. Many of these genes regulate the innate and adaptive immune system. These findings indicate that a dysregulated immune system may play a major role in the pathogenesis of psoriasis. In this article, we review the clinical and genetic epidemiology of psoriasis with a brief description of the pathogenesis of disease.