Non-coding RNA in Neurodegeneration
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- Ciccodicola, A., Ambrosio, M.R., Scarpato, M. et al. Curr Tran Geriatr Gerontol Rep (2012) 1: 219. doi:10.1007/s13670-012-0023-4
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Aging-associated chronic diseases, such as neurodegenerative disorders, have a dramatic impact on healthcare systems. Despite progresses in understanding their etiology, unsolved questions still exist. These complex disorders share a common inflammatory status and are influenced by common post-transcriptional mechanisms of gene regulation. MicroRNAs, key players in modulating gene expression, and other non-coding RNAs have specific spatial-temporal expression in the brain, and a critical role in neurogenesis and neurodegenerative diseases. Here, we review the emerging impact of non-coding RNAs in their pathogenesis, also performing a computational analysis on microRNAs and target genes. Our findings strengthen the notion of an inflammatory-related component in neurodegenerative disorders, confirming the contribution of microRNA-dependent gene expression regulation in the etiology of such diseases.