Current Nutrition Reports

, Volume 3, Issue 3, pp 213–222

Genetic Modification of the Effects of Alcohol on Metabolic and Clinical Phenotypes: A Review

  • James N. Kiage
  • Laurence O. James
  • Edmond K. Kabagambe
Genetics (GVZ Dedoussis, Section Editor)

DOI: 10.1007/s13668-014-0086-2

Cite this article as:
Kiage, J.N., James, L.O. & Kabagambe, E.K. Curr Nutr Rep (2014) 3: 213. doi:10.1007/s13668-014-0086-2

Abstract

Moderate alcohol intake is associated with improved high-density lipoprotein cholesterol, inflammation, insulin sensitivity and a lower risk of cardiovascular disease. These beneficial effects have not been consistent across studies. Genetic mechanisms that regulate alcohol intake and metabolism may in part explain the inconsistencies. In this report we review evidence of the impact of genetic variation on the effects of moderate alcohol intake on metabolic and clinical phenotypes. We focused on single nucleotide polymorphisms in major alcohol-metabolizing enzyme genes, particularly alcohol dehydrogenases (i.e., ADH1B, ADH1C and ADH7), aldehyde dehydrogenase, and cytochrome P450 2E1 because of their reported effects on gene transcription rates, enzyme activity and association with clinical endpoints. We report that while there is evidence for genetic modification of the effects of alcohol on various metabolic phenotypes, most studies are based on minimally genotyped populations. Studies using dense markers (e.g., from exome sequencing) are needed and may explain some of the inconsistencies.

Keywords

AlcoholGenetic modificationMetabolicLipidsInflammationDiabetesCardiovascular diseaseAlcohol metabolizing enzymesAlcohol dehydrogenasesCYP2E1ALDH2Nutrition

Abbreviations

ADH

Alcohol dehydrogenase

ALDH2

Aldehyde dehydrogenase 2

ApoC3

Apolipoprotein C 3

CVD

Cardiovascular disease

CRP

C-reactive protein

HDL-C

High-density lipoprotein cholesterol

sICAM-1

Soluble intercellular adhesion molecule-1

IL-6

Interleukin-6

LPL

Lipoprotein lipase

LDL-C

Low-density lipoprotein cholesterol

MEOS

Microsomal ethanol oxidizing system

PON-1

Paraoxonase-1

PCSK9

Proprotein convertase subtilisin/kexin type 9

PAI-1

Plasminogen activator inhibitor-1

SNPs

Single nucleotide polymorphisms

sVCAM-1

Soluble vascular cell adhesion molecule-1

tPA

Tissue plasminogen activator

TNF

Tumor necrosis factor

and WBC

White blood cell count

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • James N. Kiage
    • 1
  • Laurence O. James
    • 1
  • Edmond K. Kabagambe
    • 1
  1. 1.Division of Epidemiology, Department of MedicineVanderbilt University Medical CenterNashvilleUSA