Comparing two diagnostic tests when two tests are applied to same patients and test scores are given in categories
Purchase on Springer.com
$39.95 / €34.95 / £29.95*
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.
Suppose that a new diagnostic test is developed for making sharp distinction between disease A and B. To show its superiority to the standard test, the study design is introduced that the new and standard test are applied blindly to each patient in two groups, one group is definitely known being contracted with disease A and the other definitely known being contracted with disease B, where test scores are given in categories by multiple readers (raters). The design inevitably limits the number of patients used for the comparison and dependency could be introduced between the results of two tests. Application of existing statistical methods is not easy to be justified since they are based on asymptotic distributions of test statistics. We develop in this paper a method based on conditional logistic regressions that is applicable to small size of data and is useful to show the superiority of the new test to standard test by adjusting for the effect of readers in the study design. The method is applied to the data for comparing a new test and standard test for differentiating between epidermal cyst and ganglion.
- Alonzo, T.A. and Pepe, M.S. (2002). Distribution-free ROC analysis using binary regression techniques. Biostatistics, 3, 421–432. CrossRef
- Cai, T. and Pepe, M.S. (2002). Semi-parametric ROC analysis to evaluate biomarkers for disease. J. Amer. Statist. Assoc., 97, 1099–1107. CrossRef
- Delong, E.R., Delong, D.M. and Clarke-Pearson, D.L. (1988). Comparing the areas under two or more correlated receiver operating characteristic curves: A nonparametric approach. Biometrics, 44, 837–845. CrossRef
- Pepe, M.S. (2003). The statistical evaluation of medical tests for classification and prediction. Oxford University Press, New York.
- Sas Version 9.2 (2008). SAS Institute Inc., Cary, NC.
- Zhou, X.H., Obuchowski, N.A. and Mcclish, D.K. (2002). Statistical methods in diagnostic medicine. Wiley, New York. CrossRef
- Comparing two diagnostic tests when two tests are applied to same patients and test scores are given in categories
Volume 74, Issue 1 , pp 44-55
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- Primary 62J12
- Secondary 62P10, 62-07
- categorical data
- logistic regression
- ROC curve