Dermatology and Therapy

, 2:14

First online:

Open Access This content is freely available online to anyone, anywhere at any time.

Botulinum Toxins for Facial Lines: A Concise Review

  • Nicholas J. LoweAffiliated withThe Cranley ClinicUCLA School of Medicine Email author 
  • , Philippa LoweAffiliated withThe Cranley Clinic


This is a concise review of the uses of botulinum toxins (BTXs) in dermatology and cosmetic procedures. It is a clinical rather than a basic science, pharmacological review. BTX had been initially used for selectively reducing and balancing periorbital muscle activity; thereby, reducing childhood strabismus and blepharospasm. This clinical research was initiated by Dr. Alan Scott over 40 years ago. BTX type A (BTX-A) was serendipitously observed to reduce forehead frown lines in patients being treated for blepharospasm. Extensive clinical research and development resulted in widespread aesthetic uses for BTX-A by reduction of selected hyperfunctional facial muscles. BTXs are also used for reduced localized hyperhidrosis. A topical BTX-A is being developed as a potential alternative to injected BTX.


Axillary hyperhidrosis Botulinum toxins Combination treatment Dermatology Facial lines Periocular muscles Strabismus