Case Report

Dermatology and Therapy

, 2:11

First online:

Open Access This content is freely available online to anyone, anywhere at any time.

A Case Series of Refractory Cutaneous Sarcoidosis Successfully Treated with Infliximab

  • Papapit TuchindaAffiliated withDepartment of Dermatology, University of Maryland School of MedicineDepartment of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University
  • , Matthew BremmerAffiliated withDepartment of Dermatology, University of Maryland School of Medicine
  • , Anthony A. GaspariAffiliated withDepartment of Dermatology, University of Maryland School of Medicine Email author 

Abstract

Introduction

Sarcoidosis is a systemic granulomatous disease of unknown cause. The management of sarcoidosis remains problematic. Systemic and topical corticosteroids are the mainstay of therapy but may cause unacceptable side effects. Biologic therapies, such as infliximab, have recently been proposed as another treatment option for cutaneous sarcoidosis.

Case Report

The authors describe three patients who were diagnosed with cutaneous sarcoidosis with systemic involvement. All of the patients were refractory to conventional therapies but responded to infliximab therapy.

Conclusion

Infliximab is an alternative medication for refractory sarcoidosis that has a relatively benign side-effect profile. However, definite indications, dosage, interval, and duration of treatment for cutaneous sarcoidosis are not firmly established.

Keywords

Biologic Cutaneous Infliximab Sarcoidosis Therapy Treatment Tumor necrosis factor inhibitor