Review

Biologics in Therapy

, Volume 3, Issue 1, pp 1-14

First online:

Open Access This content is freely available online to anyone, anywhere at any time.

Pediatric Ulcerative Colitis: The Therapeutic Road to Infliximab

  • Pamela R. PuthoorAffiliated withUniversity of Colorado Denver School of Medicine, Department of Pediatrics, Children’s Hospital Colorado, Digestive Health Institute
  • , Edwin F. de ZoetenAffiliated withUniversity of Colorado Denver School of Medicine, Department of Pediatrics, Children’s Hospital Colorado, Digestive Health Institute Email author 

Abstract

Ulcerative colitis (UC) is a chronic inflammatory bowel disease that has significant morbidities in the pediatric population. Goals of medical therapy include induction and maintenance of remission while preserving the colon and it’s function, while minimizing the risk of treatment related morbidities. For those children who do not respond to initial therapies and progress to develop moderately-to-severely active UC, there has been a dearth of available treatments to help induce remission, necessitating long-term corticosteroid usage, with associated comorbidities of chronic steroid treatment. Significant advances have been made in medical management, including the use of biologic therapies, specifically anti-tumor necrosis factor-α monoclonal antibodies. With the Food and Drug Administration’s recent approval of the use of infliximab, a chimeric anti-tumor necrosis factor-α antibody, for children ≥6 years of age with moderately-to-severely active UC, care providers now have a new treatment regimen to offer this pediatric population.

Keywords

Gastroenterology Infliximab Pediatric Tumor necrosis factor-α Ulcerative colitis