Original Article

International Journal of Diabetes in Developing Countries

, Volume 33, Issue 2, pp 83-85

First online:

A study of non-obese diabetes mellitus in adults in a tertiary care hospital in Kerala, India

  • R. ChandniAffiliated withDepartment of Medicine, Government Medical College Email author 
  • , Binoy J. PaulAffiliated withDepartment of Medicine, Government Medical College
  • , V. UdayabhaskaranAffiliated withDepartment of Medicine, Government Medical College
  • , K. P. RamamoorthyAffiliated withDepartment of Medicine, Government Medical College

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The term Latent Autoimmune Diabetes in Adults (LADA) was introduced to define adult diabetic patients initially non–insulin-requiring but with immune markers of type 1 diabetes that, in a number of cases, progress to insulin dependency. This term has been largely used in the last few years when referring to autoimmune forms of diabetes not requiring insulin initially. In the present study we looked for the clinical, biochemical and immunological parameters of non-obese type 2 diabetes mellitus in adults and studied the frequency of antibodies to glutamic acid decarboxylase (GAD) and pancreatic islet cell antibodies (PICA). Subjects of 30 years or older with a history of diabetes of duration not more than 36 months and body mass index (BMI) of less than 23 kg/m2 were included. Fasting serum C-peptide, GAD antibody and islet cell auto antibody was estimated. GAD antibodies were positive in 25.81 %, ICA in 22.58 % and both in 9.70 % of lean diabetes. Fasting serum C-peptide was less than normal in 45.16 % of them.


Latent autoimmune diabetes in adult (LADA) Lean diabetes GAD antibody Islet cell antibody (ICA) Serum C-peptide