Journal of NeuroVirology

, Volume 20, Issue 2, pp 122–136

Microglia-mediated neuroinflammation is an amplifier of virus-induced neuropathology

Review

DOI: 10.1007/s13365-013-0188-4

Cite this article as:
Das Sarma, J. J. Neurovirol. (2014) 20: 122. doi:10.1007/s13365-013-0188-4

Abstract

Microglia, the major resident immune cells in the central nervous system (CNS) are considered as the key cellular mediators of neuroinflammatory processes. In the past few years, microglial research has become a main focus in cellular neuroimmunology and neuroinflammation. Chronic/remitting neurological disease such as multiple sclerosis (MS) has long been considered an inflammatory autoimmune disease with the infiltration of peripheral myelin-specific T cells into the CNS. With the rapid advancement in the field of microglia and astrocytic neurobiology, the term neuroinflammation progressively started to denote chronic CNS cell-specific inflammation in MS. The direct glial responses in MS are different from conventional peripheral immune responses. This review attempts to summarize current findings of neuroinflammatory responses within the CNS by direct infection of neural cells by mouse hepatitis virus (MHV) and the mechanisms by which glial cell responses ultimately contribute to the neuropathology on demyelination. Microglia can be persistently infected by MHV. Microglial activation and phagocytosis are recognized to be critically important in the pathogenesis of demyelination. Emerging evidence for the pathogenic role of microglia and the activation of inflammatory pathways in these cells in MHV infection supports the concept that microglia induced neuroinflammation is an amplifier of virus-induced neuropathology.

Keywords

Virus-induced neuroinflammationDemyelinationAxonal lossMultiple sclerosisExperimental animal model of multiple sclerosisNeuroimmunologyNeurobiology of demyelinating diseases

Supplementary material

13365_2013_188_MOESM1_ESM.doc (30 kb)
ESM 1(DOC 30 kb)

Copyright information

© Journal of NeuroVirology, Inc. 2013

Authors and Affiliations

  1. 1.Department of Biological SciencesIndian Institute of Science Education and ResearchKolkataIndia