Journal of NeuroVirology

, Volume 19, Issue 1, pp 1–9

Global NeuroAIDS Roundtable

  • Jeymohan Joseph
  • Cristian L. Achim
  • Michael J. Boivin
  • Bruce J. Brew
  • David B. Clifford
  • Deborah A. Colosi
  • Ronald J. Ellis
  • Robert K. Heaton
  • Amadou Gallo-Diop
  • Igor Grant
  • Georgette D. Kanmogne
  • Mahendra Kumar
  • Scott Letendre
  • Thomas D. Marcotte
  • Avindra Nath
  • Carlos A. Pardo
  • Robert H. Paul
  • Lynn Pulliam
  • Kevin Robertson
  • Walter RoyalIII
  • Ned Sacktor
  • Pasiri Sithinamsuwan
  • Davey M. Smith
  • Victor Valcour
  • Brian Wigdahl
  • Charles Wood
Review

DOI: 10.1007/s13365-012-0143-9

Cite this article as:
Joseph, J., Achim, C.L., Boivin, M.J. et al. J. Neurovirol. (2013) 19: 1. doi:10.1007/s13365-012-0143-9

Abstract

In May 2012, the Division of AIDS Research at the National Institute of Mental Health (NIMH) organized the “Global NeuroAIDS Roundtable” in conjunction with the 11th International Symposium on Neurovirology and the 2012 Conference on HIV in the Nervous System. The meeting was held in New York, NY, USA and brought together NIMH-funded investigators who are currently working on projects related to the neurological complications of AIDS (NeuroAIDS) in Africa, Asia, Eastern Europe, and Latin America in order to provide an opportunity to share their recent findings and discuss the challenges encountered within each country. The major goals of the roundtable were to evaluate HIV-associated neurocognitive impairment and determine if it may be directly attributable to distinct HIV subtypes or clades and to discuss the future priorities for global NeuroAIDS research. At the “Global NeuroAIDS Roundtable”, presentations of preliminary research indicated that HIV-associated neurocognitive impairment is prevalent in all countries examined regardless of which HIV clade is present in the region. The only clear-cut difference between HIV-1 clades was in relation to subtypes A and D in Uganda. However, a key point that emerged from the discussions was that there is an urgent need to standardize neurocognitive assessment methodologies across the globe before definitive conclusions can be drawn regarding the relationship between HIV clade diversity and neuropathogenesis. Future research directions were also discussed at the roundtable with particular emphasis on the potential of viral and host factor molecular interactions to impact the pathophysiology of HIV-associated neurocognitive disorders (HAND) from a global perspective.

Keywords

Human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) Acquired immunodeficiency syndrome (AIDS) HIV clade NeuroAIDS HIV-associated neurocognitive disorders (HAND) Neuropathogenesis 

Copyright information

© Journal of NeuroVirology, Inc. (outside the USA) 2013

Authors and Affiliations

  • Jeymohan Joseph
    • 1
  • Cristian L. Achim
    • 2
  • Michael J. Boivin
    • 3
  • Bruce J. Brew
    • 4
  • David B. Clifford
    • 5
  • Deborah A. Colosi
    • 1
  • Ronald J. Ellis
    • 2
  • Robert K. Heaton
    • 2
  • Amadou Gallo-Diop
    • 6
  • Igor Grant
    • 2
  • Georgette D. Kanmogne
    • 7
  • Mahendra Kumar
    • 8
  • Scott Letendre
    • 2
  • Thomas D. Marcotte
    • 2
  • Avindra Nath
    • 9
  • Carlos A. Pardo
    • 10
  • Robert H. Paul
    • 11
  • Lynn Pulliam
    • 12
  • Kevin Robertson
    • 13
  • Walter RoyalIII
    • 14
  • Ned Sacktor
    • 10
  • Pasiri Sithinamsuwan
    • 15
  • Davey M. Smith
    • 2
  • Victor Valcour
    • 12
  • Brian Wigdahl
    • 16
  • Charles Wood
    • 17
  1. 1.Division of AIDS ResearchNational Institute of Mental Health, National Institutes of HealthBethesdaUSA
  2. 2.University of CaliforniaSan DiegoUSA
  3. 3.Michigan State University, East LansingMichiganUSA
  4. 4.Departments of Neurology and HIV Medicine St Vincent’s HospitalSt Vincent’s Centre for Applied Medical Research and University of New South WalesSydneyAustralia
  5. 5.Washington University School of MedicineSt. LouisUSA
  6. 6.Université Cheikh Anta Diop de DakarDakarSenegal
  7. 7.University of NebraskaOmahaUSA
  8. 8.University of MiamiMiami, FloridaUSA
  9. 9.National Institute of Neurological Disorders and Stroke, National Institutes of HealthBethesdaUSA
  10. 10.Johns Hopkins UniversityBaltimoreUSA
  11. 11.University of MissouriSt. LouisUSA
  12. 12.University of CaliforniaSan FranciscoUSA
  13. 13.University of North CarolinaChapel HillUSA
  14. 14.University of MarylandBaltimoreUSA
  15. 15.Phramongkutkloa HospitalBangkokThailand
  16. 16.Drexel UniversityPhiladelphiaUSA
  17. 17.University of NebraskaLincolnUSA