Journal of NeuroVirology

, Volume 17, Issue 6, pp 552–558

The herpes simplex virus type 1 latency associated transcript locus is required for the maintenance of reactivation competent latent infections

Article

DOI: 10.1007/s13365-011-0071-0

Cite this article as:
Thompson, R.L. & Sawtell, N.M. J. Neurovirol. (2011) 17: 552. doi:10.1007/s13365-011-0071-0

Abstract

Herpes simplex virus (HSV) establishes latent infections in sensory neurons from which it can periodically reactivate and cause recurrent disease and transmission to new hosts. Little is known about the virally encoded mechanisms that influence the maintenance of HSV latent infectious and modulate the frequency of virus reactivation from the latent state. Here, we report that the latency associated transcript locus of HSV-1 is required for long-term maintenance of reactivation competent latent infections.

Keywords

Herpes simplex virus type 1Latent infectionsInnervating sensory neuronsLatency associated transcriptMaintenance of latencyReactivationMouse model

Copyright information

© Journal of NeuroVirology, Inc. 2011

Authors and Affiliations

  1. 1.Department of Molecular Genetics, Biochemistry and MicrobiologyUniversity of Cincinnati College of MedicineCincinnatiUSA
  2. 2.Department of Pediatrics, Division of Infectious DiseasesCincinnati Children’s Hospital Medical CenterCincinnatiUSA