Journal of NeuroVirology

, Volume 18, Issue 1, pp 69–73

Failure to clear intra-monocyte HIV infection linked to persistent neuropsychological testing impairment after first-line combined antiretroviral therapy

  • B. Shiramizu
  • J. Ananworanich
  • T. Chalermchai
  • U. Siangphoe
  • D. Troelstrup
  • C. Shikuma
  • V. De Grutolla
  • P. Sithinamsuwan
  • P. Praihirunkit
  • S. Rattanamanee
  • V. Valcour
  • on behalf of the SEARCH 001.1 Study Group
Short Communication

DOI: 10.1007/s13365-011-0068-8

Cite this article as:
Shiramizu, B., Ananworanich, J., Chalermchai, T. et al. J. Neurovirol. (2012) 18: 69. doi:10.1007/s13365-011-0068-8

Abstract

HIV-associated neurocognitive disorders (HAND) persist despite plasma HIV RNA suppression with antiretrovirals (ARV). Sequestered reservoirs in the central nervous system and circulating monocytes are theorized to contribute to persistent brain injury. We previously demonstrated that elevated intracellular HIV DNA from circulating cells was associated with HAND in ARV-treated and ARV-naive subjects. We now report that failure to suppress intra-monocyte HIV DNA 3.5 years after initiating ARV is linked to persistent HAND and subjects with dementia are least likely to suppress intra-monocyte HIV DNA at 3.5 years. These findings suggest that antiviral strategies may need to target intra-monocyte HIV DNA.

Keyword

HIV Dementia HIV DNA Neurocognitive 

Copyright information

© Journal of NeuroVirology, Inc. 2011

Authors and Affiliations

  • B. Shiramizu
    • 1
    • 2
    • 3
    • 11
  • J. Ananworanich
    • 1
    • 4
    • 5
    • 6
  • T. Chalermchai
    • 4
  • U. Siangphoe
    • 4
  • D. Troelstrup
    • 1
  • C. Shikuma
    • 1
    • 3
    • 4
  • V. De Grutolla
    • 7
  • P. Sithinamsuwan
    • 8
  • P. Praihirunkit
    • 4
  • S. Rattanamanee
    • 4
  • V. Valcour
    • 4
    • 9
    • 10
  • on behalf of the SEARCH 001.1 Study Group
  1. 1.Hawaii Center for AIDSUniversity of Hawaii-ManoaHonoluluUSA
  2. 2.Department of PediatricsUniversity of Hawaii-ManoaHonoluluUSA
  3. 3.Department of MedicineUniversity of Hawaii-ManoaHonoluluUSA
  4. 4.Southeast Asia Research Collaboration with Hawaii (SEARCH)The Thai Red Cross AIDS Research CentreBangkokThailand
  5. 5.Faculty of MedicineChulalongkorn HospitalBangkokThailand
  6. 6.HIV Netherlands Australia Thailand Research CollaborationThe Thai Red Cross AIDS Research CentreBangkokThailand
  7. 7.Department of BiostatisticsHarvard School of Public HealthBostonUSA
  8. 8.Division of Neurology, Department of MedicinePhramongkutklao HospitalBangkokThailand
  9. 9.Memory and Aging Center, Department of NeurologyUCSFSan FranciscoUSA
  10. 10.Division of Geriatric Medicine, Department of MedicineUCSFSan FranciscoUSA
  11. 11.Hawaii John A. Burns School of MedicineHawaii Center for AIDSHonoluluUSA