Research Article

Journal of The American Society for Mass Spectrometry

, Volume 25, Issue 9, pp 1515-1520

Direct Analysis of Large Living Organism by Megavolt Electrostatic Ionization Mass Spectrometry

  • Kwan-Ming NgAffiliated withDepartment of Chemistry and State Key Laboratory of Synthetic Chemistry, The University of Hong Kong Email author 
  • , Ho-Wai TangAffiliated withDepartment of Chemistry and State Key Laboratory of Synthetic Chemistry, The University of Hong Kong
  • , Sin-Heng ManAffiliated withDepartment of Chemistry and State Key Laboratory of Synthetic Chemistry, The University of Hong Kong
  • , Pui-Yuk MakAffiliated withDepartment of Chemistry and State Key Laboratory of Synthetic Chemistry, The University of Hong Kong
  • , Yi-Ching ChoiAffiliated withDepartment of Chemistry and State Key Laboratory of Synthetic Chemistry, The University of Hong Kong
  • , Melody Yee-Man WongAffiliated withDepartment of Chemistry and State Key Laboratory of Synthetic Chemistry, The University of Hong Kong

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Abstract

A new ambient ionization method allowing the direct chemical analysis of living human body by mass spectrometry (MS) was developed. This MS method, namely Megavolt Electrostatic Ionization Mass Spectrometry, is based on electrostatic charging of a living individual to megavolt (MV) potential, illicit drugs, and explosives on skin/glove, flammable solvent on cloth/tissue paper, and volatile food substances in breath were readily ionized and detected by a mass spectrometer.

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Key words

Megavolt electrostatic ionization Large living organism Direct analysis Mass spectrometry