Research Article

Journal of The American Society for Mass Spectrometry

, Volume 25, Issue 3, pp 303-309

First online:

Advantages of Monodisperse and Chemically Robust “SpheriCal” Polyester Dendrimers as a “Universal” MS Calibrant

  • Scott M. GraysonAffiliated withDepartment of Chemistry, Tulane University Email author 
  • , Brittany K. MyersAffiliated withDepartment of Chemistry, Tulane University
  • , Jonas BengtssonAffiliated withPolymer Factory Sweden AB
  • , Michael MalkochAffiliated withPolymer Factory Sweden ABDepartment of Fiber and Polymer Technology, School of Chemical Science and Engineering, KTH Royal Institute of Technology

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The utilization of dendrimer calibrants as an alternative to peptides and proteins for high mass calibration is explored. These synthetic macromolecules exhibited a number of attractive advantages, including exceptional shelf-lives, broad compatibility with a wide range of matrices and solvents, and evenly spaced calibration masses across the mass range examined, 700–30,000 u. The exceptional purity of these dendrimers and the technical simplicity of this calibration platform validate their broad relevance for high molecular weight mass spectrometry.

Key words

Calibrant Dendrimer Calibration Polymer MALDI-TOF MS