Journal of Applied Genetics

, Volume 54, Issue 3, pp 271–283

Research progress in allele-specific expression and its regulatory mechanisms

Animal Genetics • Review

DOI: 10.1007/s13353-013-0148-y

Cite this article as:
Gaur, U., Li, K., Mei, S. et al. J Appl Genetics (2013) 54: 271. doi:10.1007/s13353-013-0148-y

Abstract

Although the majority of genes are expressed equally from both alleles, some genes are differentially expressed. Organisms possess characteristics to preferentially express a particular allele under regulatory factors, which is termed allele-specific expression (ASE). It is one of the important genetic factors that lead to phenotypic variation and can be used to identify the variance of gene regulation factors. ASE indicates mechanisms such as DNA methylation, histone modifications, and non-coding RNAs function. Here, we review a broad survey of progress in ASE studies, and what this simple yet very effective approach can offer in functional genomics, and possible implications toward our better understanding of the underlying mechanisms of complex traits.

Keywords

Phenotypic variationAllele-specific expressionRegulatory mechanismGenetic and epigenetic factors

Copyright information

© Institute of Plant Genetics, Polish Academy of Sciences, Poznan 2013

Authors and Affiliations

  1. 1.Institute of Animal Science and Veterinary MedicineHubei Academy of Agricultural SciencesWuhanPeople’s Republic of China
  2. 2.Hubei Key Laboratory of Animal Embryo Engineering and Molecular BreedingWuhanPeople’s Republic of China
  3. 3.Beijing Institute of Animal Science and Veterinary MedicineChinese Academy of Agricultural SciencesBeijingPeople’s Republic of China