Drug Delivery and Translational Research

, Volume 1, Issue 4, pp 289–298

Electrostatic droplets assisted synthesis of alginate microcapsules

  • Keng-Shiang Huang
  • Chih-Hui Yang
  • Yung-Sheng Lin
  • Chih-Yu Wang
  • Kang Lu
  • Yu-Fan Chang
  • Yi-Ling Wang
Research Article

DOI: 10.1007/s13346-011-0020-8

Cite this article as:
Huang, KS., Yang, CH., Lin, YS. et al. Drug Deliv. and Transl. Res. (2011) 1: 289. doi:10.1007/s13346-011-0020-8

Abstract

This paper demonstrates a proof-of-concept approach for encapsulating the insulin and Fe3O4 nanoparticles into size-controllable alginate microcapsules utilizing the electrostatic droplets (ESD) technique. We have established that the combination of ESD and external gelation is quite effective in producing uniform-sized polymer particles. In addition, using the external gelation technique, the droplets containing a sodium-alginate were gelled in situ by immersion in Ca2+, Ba2+, or Cu2+ ions for a few minutes. The results show that different-type divalent cations caused various surface features to appear on the microcapsules (e.g., cracking, orange peel, pitting, splitting, wrinkling, etc.). The particle size can be adjusted from a few micrometers to ca. 1,000 μm by electrostatic force. The microcapsules can be made magnetic by incorporating a super-paramagnetic nanomaterial (e.g., Fe3O4 nanoparticles) during the preparation. The composite magnetic microcapsules are potential candidates for a magnetic-responsive drug delivery system. In addition, our results show that the encapsulation and in vitro release of a model drug, insulin, can enhance the effect of the controlled release. These microcapsules are addressable by an external magnetic field and are capable of loading a model drug and releasing it in a highly differential drug release profile. We have demonstrated that the appropriate magnetic field intensity for different release patterns is predictable, which enables a better application of microcapsules as a smart drug carrier.

Keywords

Electrostatic Microcapsules Encapsulation Insulin Monodisperse 

Copyright information

© Controlled Release Society 2011

Authors and Affiliations

  • Keng-Shiang Huang
    • 1
  • Chih-Hui Yang
    • 2
  • Yung-Sheng Lin
    • 3
  • Chih-Yu Wang
    • 4
  • Kang Lu
    • 5
  • Yu-Fan Chang
    • 2
  • Yi-Ling Wang
    • 2
  1. 1.The School of Chinese Medicine for Post-BaccalaureateI-Shou UniversityKaohsiungTaiwan
  2. 2.Department of Biological Science and TechnologyI-Shou UniversityKaohsiungTaiwan
  3. 3.Department of Applied Cosmetology and Graduate Institute of Cosmetic ScienceHungkuang UniversityTaichungTaiwan
  4. 4.Department of Biomedical EngineeringI-Shou UniversityKaohsiungTaiwan
  5. 5.Department of Physical TherapyI-Shou UniversityKaohsiungTaiwan