, Volume 3, Issue 2, pp 65-67
Date: 05 Jun 2012

Red wine acts through a familiar drug target

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Resveratrol, a natural polyphenol first identified and named by a Japanese chemist in 1940 [1], is present in many plant products, including grape skin. It has been the focus of much attention recently because it provides a variety of potential health benefits, in particular protection from various age-related conditions (such as diabetes mellitus, vascular diseases, cognitive disorders, and cancer), and increases life span [24]. Given that red wine is rich in resveratrol, and that moderate wine consumption has been shown to lower cardiovascular risk [5], the intake of resveratrol through the drinking of red wine may contribute to the “French paradox”—which refers to the fact that the mortality due to cardiovascular diseases is lower in France than in other European countries despite similar lifestyle-related risk factors [6]. Sirt1, an NAD+-dependent protein deacetylase, is thought to play an important role in the action of resveratrol [2]. Resveratrol stimulates the activity of Sirt ...