Indian Journal of Virology

, Volume 23, Issue 1, pp 36–38

Low Level of Cross-Reactive Antibodies to Pandemic Influenza (H1N1) 2009 Virus in Humans in Pre-Pandemic Period in Maharashtra, India

  • Sadhana S. Kode
  • Shailesh D. Pawar
  • Babasaheb V. Tandale
  • Saurabh S. Parkhi
  • Tanaji D. Barde
  • Akhilesh C. Mishra
Short Communication

DOI: 10.1007/s13337-011-0055-y

Cite this article as:
Kode, S.S., Pawar, S.D., Tandale, B.V. et al. Indian J. Virol. (2012) 23: 36. doi:10.1007/s13337-011-0055-y

Abstract

In India, the first outbreak of pandemic influenza (H1N1) 2009 (H1N1pdm) was reported from Panchgani, Maharashtra, in June 2009. Studies from several countries have revealed different levels of pre-existing immunity to H1N1pdm 2009 in various age groups. This study was undertaken using age-stratified pre-pandemic human sera to understand baseline cross-reactivity of antibodies against H1N1pdm. Using cut off antibody titers 20 and 40, overall cross-reactivity was 2.1 and 0.9% respectively by microneutralization assay; 1.2% and 0.7% by haemagglutination inhibition assay, respectively. Results showed higher baseline antibodies and cross-reactive antibodies in the 0–19 age group whereas the elderly age group (≥60) showed no cross-reactivity to H1N1pdm. The higher baseline and cross-reactive antibodies in 0–19 years age group could be because of higher positivity to seasonal H1N1 in that age group. Overall, low level of cross-reactive antibodies to H1N1pdm virus were found in humans in pre-pandemic period in Maharashtra, India.

Keywords

Pandemic influenza (H1N1) 2009 Hemagglutination inhibition assay Microneutralization assay Cross-reactive antibodies 

Copyright information

© Indian Virological Society 2012

Authors and Affiliations

  • Sadhana S. Kode
    • 1
  • Shailesh D. Pawar
    • 1
  • Babasaheb V. Tandale
    • 1
  • Saurabh S. Parkhi
    • 1
  • Tanaji D. Barde
    • 1
  • Akhilesh C. Mishra
    • 2
  1. 1.National Institute of Virology (NIV)-Microbial Containment Complex (MCC)PuneIndia
  2. 2.National Institute of VirologyPuneIndia

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