Indian Pediatrics

, Volume 50, Issue 11, pp 1033–1040

Newer anti-epileptic drugs

Review Article

DOI: 10.1007/s13312-013-0284-9

Cite this article as:
Aneja, S. & Sharma, S. Indian Pediatr (2013) 50: 1033. doi:10.1007/s13312-013-0284-9

Abstract

Need and Purpose of review

A number of newer anti-epileptic drugs have been developed in the last few years to improve the treatment outcomes in epilepsy. In this review, we discuss the use of newer anti-epileptic drugs in children.

Methods used for locating, selecting, extracting and synthesizing data

MEDLINE search (1966–2013) was performed using terms “newer anti-epileptic drugs”, “Oxcarbazepine”, vigabatrin”, topiramate”, “zonisamide”, “levetiracetam”, “lacosamide”, “rufinamide”, “stiripentol”, “retigabine”, “eslicarbazepine”, “brivaracetam”, “ganaxolone” and “perampanel” for reports on use in children. Review articles, practice parameters, guidelines, systematic reviews, meta-analyses, randomized controlled trials, cohort studies, and case series were included. The main data extracted included indications, efficacy and adverse effects in children.

Main conclusions

Oxcarbazepine is established as effective initial monotherapy for children with partial-onset seizures. Vigabatrin is the drug of choice for infantile spasms associated with tuberous sclerosis. Lamotrigine, levetiracetam and lacosamide are good add-on drugs for patients with partial seizures. Lamotrigine may be considered as monotherapy in adolescent females with idiopathic generalized epilepsy. Levetiracetam is a good option as monotherapy for females with juvenile myoclonic epilepsy. Topiramate is a good add-on drug in patients with epileptic encephalopathies such as Lennox-Gastaut syndrome and myoclonic astatic epilepsy.

Keywords

Refractory epilepsyEpileptic encephalopathiesOxcarbazepineVigabatrinLamotrigineLevetiracetam

Copyright information

© Indian Academy of Pediatrics 2013

Authors and Affiliations

  1. 1.Department of PediatricsLady Hardinge Medical College and associated Kalawati Saran Children’s HospitalNew DelhiIndia
  2. 2.Lady Hardinge Medical College and associated Kalawati Saran Children’s HospitalNew DelhiIndia