Propranolol therapy for infantile hemangioma
- Nivedita GunturiAffiliated withDepartments of Pediatrics, Sri Ramachandra UniversityDepartments of Pediatric Surgery, Sri Ramachandra University
- , Sriram RamgopalAffiliated withDepartment of Neurology, Boston Children’s Hospital, BostonDepartments of Pediatric Surgery, Sri Ramachandra University
- , Subramanian BalagopalAffiliated withDepartments of Pediatrics, Sri Ramachandra UniversityDepartments of Pediatric Surgery, Sri Ramachandra University
- , Julius Xavier ScottAffiliated withDepartments of Pediatric Hemato-Oncology, Sri Ramachandra UniversityDepartments of Pediatric Surgery, Sri Ramachandra UniversityPediatric Hemato-Oncology, Sri Ramachandra University Email author
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There has been widespread interest surrounding the use of beta-blockers (i.e. propranolol, timolol, nadolol, acebutolol) in the treatment of infantile hemangiomas (IH).
To review literature evaluating treatment of IH with propranolol.
We conducted a literature search on PubMed and investigated for case reports, case series, and controlled trials by using search terms including “hemangioma” and “propranolol.”
Data suggest that beta-blockers are efficacious in cutaneous, orbital, subglottic, and hepatic hemangiomas and assist in the resolution of ulcerated hemangiomas. Improvement has also been documented in children with PHACE syndrome. Propranolol produces favorable results in children who do not respond to steroids and with no long-term adverse effects. Propranolol should be administered with caution due to rare but serious side effects including hypoglycemia, wheezing, hypotension, and bradycardia. Additionally, recurrence of lesions following the cessation of treatment has been documented.
Although large-scale randomized controlled trials must be conducted in order to further evaluate the safety and the possible role of propranolol in the treatment of IH, the reviewed literature suggests that propranolol carries promise as a potential replacement for corticosteroids as first-line therapy or as a part of a multimodal approach.
Key wordsBeta-blockers Capillary hemangioma Infants PHACE association Propranolol
- Propranolol therapy for infantile hemangioma
Volume 50, Issue 3 , pp 307-313
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- Capillary hemangioma
- PHACE association
- Author Affiliations
- 198. Departments of Pediatrics, Sri Ramachandra University, Chennai, India
- 498. Departments of Pediatric Surgery, Sri Ramachandra University, Chennai, India
- 298. Department of Neurology, Boston Children’s Hospital, Boston, Massachusetts, USA
- 398. Departments of Pediatric Hemato-Oncology, Sri Ramachandra University, Chennai, India
- 598. Pediatric Hemato-Oncology, Sri Ramachandra University, 1, Ramachandra Nagar, Porur, Chennai, 600 116, India